Please wait, while we are loading the content...
Please wait, while we are loading the content...
| Content Provider | PubMed Central |
|---|---|
| Author | Gao, Ang Wang, Shijiang Fu, Zheng Sun, Xindong Yu, Jinming Meng, Xue |
| Copyright Year | 2015 |
| Abstract | Background: To investigate whether during/post-radiotherapy FDG uptake locations within tumors is likely identified using a pre-radiotherapy scan for non-small cell lung cancer (NSCLC), ultimately enabling confirm that a suitable metabolically active sub-volume pre-radiotherapy of the primary tumor for radiation boosting target. Methods: Patients with a pathologically proven inoperable stage II-III NSCLC were enrolled. For each patient, one pre-radiotherapy (pre-RT) plus one following 40Gy during-radiotherapy (during-RT) or post-radiotherapy (post-RT) FDG PET/CT scans were available. On pre-RT scan, the high FDG uptake region were auto-delineated using several percentage of the maximal standardized uptake value (SUVmax) thresholds, varying from 40% to 70%. On during-RT scan, FDG uptake region is delineated by 40% SUVmax, manual method respectively. With the FDG-positive areas on post-RT images is defined as 80% SUVmax. The overlap fractions (OFs) were calculated between pre-RT scan and during-RT or post-RT scan. Semi-quantitative assessment was used to determine SUVmax and metabolic tumor volume (MTV). The SUVmax changes during-RT representing the radiotherapy (RT) early metabolic response is attainable. Then, a spearman correlation was used to analysis the correlation between percentage changes in SUVmax during-RT and SUVmax-threshold definition volume pre-RT. Results: Of those 7 patients, a total of 16 FDG-PET scans were acquired. 5 patients were received pre-RT and during-RT scan, while 2 of these 5 patients underwent both post-RT scan. 2 patients were received FDG-PET/CT scan pre-RT and post-RT. The pre-RT scan threshold delineations of 50% SUVmax had a large OF with the 40% SUVmax threshold and manual method delineation on the during-RT scan, 74.3% and 84.4%, respectively. Comparably, the 80% SUVmax on the post-RT scan also largely corresponded (OF > 72%) with the 50% SUVmax threshold and the volume was small compared to the gross tumor volume (GTV), accounting for 29.4%. However, the 50% SUVmax threshold was not correlate with the percentage change in SUVmax (P > 0.05). Conclusions: A pre-RT FDG-PET scan allows for the identification of during- and post-RT FDG uptake locations. The volume defined by 50% SUVmax may be a suitable threshold for dose escalation. |
| Ending Page | 7568 |
| Starting Page | 7561 |
| File Format | |
| ISSN | 19405901 |
| e-ISSN | 19405901 |
| Journal | International Journal of Clinical and Experimental Medicine |
| Issue Number | 5 |
| Volume Number | 8 |
| Language | English |
| Publisher | e-Century Publishing Corporation |
| Publisher Date | 2015-05-15 |
| Access Restriction | Open |
| Rights Holder | e-Century Publishing Corporation |
| Subject Keyword | Research in Higher Education |
| Content Type | Text |
| Resource Type | Article |
| Subject | Biochemistry, Genetics and Molecular Biology |
National Digital Library of India (NDLI) is a virtual repository of learning resources which is not just a repository with search/browse facilities but provides a host of services for the learner community. It is sponsored and mentored by Ministry of Education, Government of India, through its National Mission on Education through Information and Communication Technology (NMEICT). Filtered and federated searching is employed to facilitate focused searching so that learners can find the right resource with least effort and in minimum time. NDLI provides user group-specific services such as Examination Preparatory for School and College students and job aspirants. Services for Researchers and general learners are also provided. NDLI is designed to hold content of any language and provides interface support for 10 most widely used Indian languages. It is built to provide support for all academic levels including researchers and life-long learners, all disciplines, all popular forms of access devices and differently-abled learners. It is designed to enable people to learn and prepare from best practices from all over the world and to facilitate researchers to perform inter-linked exploration from multiple sources. It is developed, operated and maintained from Indian Institute of Technology Kharagpur.
Learn more about this project from here.
NDLI is a conglomeration of freely available or institutionally contributed or donated or publisher managed contents. Almost all these contents are hosted and accessed from respective sources. The responsibility for authenticity, relevance, completeness, accuracy, reliability and suitability of these contents rests with the respective organization and NDLI has no responsibility or liability for these. Every effort is made to keep the NDLI portal up and running smoothly unless there are some unavoidable technical issues.
Ministry of Education, through its National Mission on Education through Information and Communication Technology (NMEICT), has sponsored and funded the National Digital Library of India (NDLI) project.
| Sl. | Authority | Responsibilities | Communication Details |
|---|---|---|---|
| 1 | Ministry of Education (GoI), Department of Higher Education |
Sanctioning Authority | https://www.education.gov.in/ict-initiatives |
| 2 | Indian Institute of Technology Kharagpur | Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project | https://www.iitkgp.ac.in |
| 3 | National Digital Library of India Office, Indian Institute of Technology Kharagpur | The administrative and infrastructural headquarters of the project | Dr. B. Sutradhar bsutra@ndl.gov.in |
| 4 | Project PI / Joint PI | Principal Investigator and Joint Principal Investigators of the project |
Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon |
| 5 | Website/Portal (Helpdesk) | Queries regarding NDLI and its services | support@ndl.gov.in |
| 6 | Contents and Copyright Issues | Queries related to content curation and copyright issues | content@ndl.gov.in |
| 7 | National Digital Library of India Club (NDLI Club) | Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach | clubsupport@ndl.gov.in |
| 8 | Digital Preservation Centre (DPC) | Assistance with digitizing and archiving copyright-free printed books | dpc@ndl.gov.in |
| 9 | IDR Setup or Support | Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops | idr@ndl.gov.in |
|
Loading...
|