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Functional and anatomical cortical underconnectivity in autism: Evidence from an fMRI study of an executive function task and corpus callosum morphometry

Content Provider	PubMed Central
Author	Just, Marcel Adam Cherkassky, Vladimir L. Keller, Timothy A. Kana, Rajesh K. Minshew, Nancy J.
Abstract	The brain activation of a group of high-functioning autistic participants was measured using fMRI during the performance of a Tower of London task, in comparison to a control group matched with respect to IQ, age, and gender. The two groups generally activated the same cortical areas to similar degrees. However, there were three indications of underconnectivity in the group with autism. First, the degree of synchronization (i.e. the functional connectivity, or the correlation of the time series of the activation) between the frontal and parietal areas of activation was lower for the autistic than the control participants. Second, relevant parts of the corpus callosum, through which many of the bilaterally activated cortical areas communicate, were smaller in cross-sectional area in the autistic participants. Third, within the autism group but not within the control group, the size of the genu of the corpus callosum was correlated with frontal-parietal functional connectivity. These findings suggest that the neural basis of altered cognition in autism entails a lower degree of integration of information across certain cortical areas resulting from reduced intra-cortical connectivity. The results add support to a new theory of cortical underconnectivity in autism, which posits a deficit in integration of information at the neural and cognitive levels.
Related Links	http://dx.doi.org/10.1093/cercor/bhl006
Ending Page	961
Page Count	11
Starting Page	951
File Format	PDF
ISSN	10473211
e-ISSN	14602199
Journal	Cerebral cortex (New York, N.Y. : 1991)
Issue Number	4
Volume Number	17
Language	English
Publisher Date	2006-05-01
Access Restriction	Open
Subject Keyword	Medicine(all) Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Cognitive Neuroscience Cellular and Molecular Neuroscience

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Functional and Anatomical Cortical Underconnectivity in Autism: Evidence from an fMRI Study of an Executive Function Task and Corpus Callosum Morphometry

From an fmri study of an executive function task and corpus callosum.

From an fmri study of an executive function task and corpus callosum (2007).

Functional and Anatomical Cortical Underconnectivity in Autism: Evidence from an fMRI Study of an Executive Function Task and Corpus Callosum (2007)

Functional and anatomical cortical underconnectivity in autism: Evidence from an fMRI study of an executive function task and corpus callosum morphometry (2007)

Functional and anatomical cortical underconnectivity in autism: Evidence from an fMRI study of an executive function task and corpus callosum morphometry (2007)

Functional and anatomical cortical under connectivity in autism: evidence from an FMRI study of an executive function task and corpus callosum morphometry (2007)

In Press, Cerebral Cortex

Cerebral Cortex doi:10.1093/cercor/bhl006 Functional and Anatomical Cortical Underconnectivity in Autism: Evidence from an fMRI Study of an Executive Function Task and Corpus Callosum (2006)

Functional and anatomical cortical underconnectivity in autism: Evidence from an fMRI study of an executive function task and corpus callosum morphometry

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Cerebral Cortex doi:10.1093/cercor/bhl006 Functional and Anatomical Cortical Underconnectivity in Autism: Evidence from an fMRI Study of an Executive Function Task and Corpus Callosum (2006)

Functional and anatomical cortical underconnectivity in autism: Evidence from an fMRI study of an executive function task and corpus callosum morphometry