NDLI: Biomodification of PCL Scaffolds with Matrigel, HA, and SR1 Enhances De Novo Ectopic Bone Marrow Formation Induced by rhBMP-2

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Biomodification of PCL Scaffolds with Matrigel, HA, and SR1 Enhances De Novo Ectopic Bone Marrow Formation Induced by rhBMP-2

Content Provider	PubMed Central
Author	Bao, Wenjing Gao, Mei Cheng, Yanyan Lee, Hyun Jae Zhang, Qinghao Hemingway, Susan Luo, Zhibo Krol, Andrzej Yang, Guanlin Jing, An
Copyright Year	2015
Abstract	The de novo formation of ectopic bone marrow was induced using 1.2-mm-thin polycaprolactone (PCL) scaffolds biomodified with several different biomaterials. In vivo investigations of de novo bone and bone marrow formation indicated that subcutaneous implantation of PCL scaffolds coated with recombinant human bone morphogenetic protein-2 (rhBMP-2) plus Matrigel, hydroxyapatite (HA), or StemRegenin 1 (SR1) improved formation of bone and hematopoietic bone marrow as determined by microcomputed tomography, and histological and hematopoietic characterizations. Our study provides evidence that thin PCL scaffolds biomodified with Matrigel, HA, and SR1 mimic the environments of real bone and bone marrow, thereby enhancing the de novo ectopic bone marrow formation induced by rhBMP-2. This ectopic bone marrow model will serve as a unique and essential tool for basic research and for clinical applications of postnatal tissue engineering and organ regeneration.
Related Links	http://dx.doi.org/10.1089/biores.2015.0020
Ending Page	306
Page Count	9
Starting Page	298
File Format	PDF
ISSN	21647860
e-ISSN	21647860
Journal	BioResearch Open Access
Issue Number	1
Volume Number	4
Language	English
Publisher	Mary Ann Liebert, Inc.
Access Restriction	Open
Rights Holder	Mary Ann Liebert, Inc.
Subject Keyword	Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Biochemistry, Genetics and Molecular Biology

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