NDLI: Coregulation of Ion Channel Conductances Preserves Output in a Computational Model of a Crustacean Cardiac Motor Neuron

Content Provider	PubMed Central
Author	Ball, John M. Franklin, Clarence C. Tobin, Anne-elise Schulz, David J. Nair, Satish S.
Copyright Year	2010
Abstract	Similar activity patterns at both neuron and network levels can arise from different combinations of membrane and synaptic conductance values. A strategy by which neurons may preserve their electrical output is via cell type-dependent balances of inward and outward currents. Measurements of mRNA transcripts that encode ion channel proteins within motor neurons in the crustacean cardiac ganglion recently revealed correlations between certain channel types. To determine whether balances of intrinsic currents potentially resulting from such correlations preserve certain electrical cell outputs, we developed a nominal biophysical model of the crustacean cardiac ganglion using biological data. Predictions from the nominal model showed that coregulation of ionic currents may preserve the key characteristics of motor neuron activity. We then developed a methodology of sampling a multidimensional parameter space to select an appropriate model set for meaningful comparison with variations in correlations seen in biological datasets.
Related Links	http://dx.doi.org/10.1523/jneurosci.6435-09.2010
Ending Page	8649
Page Count	13
Starting Page	8637
File Format	PDF
ISSN	02706474
e-ISSN	15292401
Journal	The Journal of neuroscience : the official journal of the Society for Neuroscience
Issue Number	25
Volume Number	30
Language	English
Publisher Date	2010-06-23
Access Restriction	Open
Subject Keyword	Neuroscience(all) Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Neuroscience

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Crustacean cardiac ganglion model reveals constraints on morphology and conductances

Animal-to-animal variability in the phasing of the crustacean cardiac motor pattern: an experimental and computational analysis

A COMPUTATIONAL MODEL OF MOTOR NEURON DEGENERATION

Conduits of life’s spark: A perspective on ion channel research since the birth of Neuron

Focal Transplantation-based Astrocyte Replacement is Neuroprotective in a Model of Motor Neuron Disease

Blocking the mitochondrial apoptotic pathway preserves motor neuron viability and function in a mouse model of amyotrophic lateral sclerosis

The primary locus of motor neuron death in an ALS–PDC mouse model

How multiple conductances determine electrophysiological properties in a multicompartment model

Spike-frequency dependent coregulation of multiple ionic conductances in fast-spiking cells forces a metabolic tradeoff

Coregulation of Ion Channel Conductances Preserves Output in a Computational Model of a Crustacean Cardiac Motor Neuron

Similar Documents

Crustacean cardiac ganglion model reveals constraints on morphology and conductances

Animal-to-animal variability in the phasing of the crustacean cardiac motor pattern: an experimental and computational analysis

A COMPUTATIONAL MODEL OF MOTOR NEURON DEGENERATION

Conduits of life’s spark: A perspective on ion channel research since the birth of Neuron

Focal Transplantation-based Astrocyte Replacement is Neuroprotective in a Model of Motor Neuron Disease

Blocking the mitochondrial apoptotic pathway preserves motor neuron viability and function in a mouse model of amyotrophic lateral sclerosis

The primary locus of motor neuron death in an ALS–PDC mouse model

How multiple conductances determine electrophysiological properties in a multicompartment model

Spike-frequency dependent coregulation of multiple ionic conductances in fast-spiking cells forces a metabolic tradeoff

Coregulation of Ion Channel Conductances Preserves Output in a Computational Model of a Crustacean Cardiac Motor Neuron