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| Content Provider | PubMed Central |
|---|---|
| Author | Juan, Sepulveda-sanchez Ramos, Ana Hilario, Amaya Velasco, Guillermo De Castellano, Daniel Torre, Marta Garcia De La Rodon, Jordi Lahn, Michael F. |
| Copyright Year | 2015 |
| Abstract | Transforming growth factor-β (TGF-β) signaling is associated with tumor progression and vascularization in malignant glioma. In the present study, magnetic resonance imaging was used to evaluate changes in the size and vascularity of glioblastomas in 12 patients who were treated with lomustine and the novel inhibitor of TGF-β signaling, LY2157299 monohydrate. A response in tumor size was observed in 2 of the 12 patients; in 1 of these 2 patients, a reduction in vascular permeability and perfusion was also detected. The effect was observed following 4 cycles of treatment (~3 months). Changes in vascularity have not previously been attributed to treatment with lomustine; therefore, the effect may be associated with LY2157299 treatment. LY2157299 does not appear to have an anti-angiogenic effect when combined with lomustine, and hence may have a different mechanism of action profile compared with anti-angiogenic drugs. |
| Related Links | http://dx.doi.org/10.3892/ol.2015.3106 |
| Starting Page | 2442 |
| File Format | |
| ISSN | 17921082 |
| e-ISSN | 17921082 |
| Journal | Oncology Letters |
| Issue Number | 6 |
| Volume Number | 9 |
| Language | English |
| Publisher | D.A. Spandidos |
| Publisher Date | 2015-06-01 |
| Access Restriction | Open |
| Rights Holder | D.A. Spandidos |
| Subject Keyword | Research in Higher Education |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cancer Research Oncology |
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