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| Content Provider | PubMed Central |
|---|---|
| Author | Han, Chao Ding, Weiliang Jiang, Wenjie Chen, Yu Hang, Dongyuan Gu, Daming Jiang, Guojun Tan, Yongfei Ge, Zhijun Ma, Tieliang |
| Copyright Year | 2015 |
| Abstract | Previous studies on the antioxidant activity of sedatives have predominantly been in vitro investigations that are lacking clinical data, resulting in conclusion without cogency. The aim of the present prospective, randomized study was to use single sedative drugs for anesthesia induction to compare their antioxidant properties. The effects on the antioxidant system of midazolam, propofol and dexmedetomidine were assessed using oxidative stress indicators and micronuclei (MN). Forty-nine patients undergoing esophageal cancer radical prostatectomy were selected. Midazolam, propofol and dexmedetomidine were used to induce anesthesia. Venous blood samples were obtained prior to and at 2 and at 24 h after surgery, and oxidative stress indicators were detected using the appropriate kits. The cytokinesis-block micronucleus cytome assay was executed and the frequencies of MN, nucleoplasmic bridges and nuclear buds were examined. It was found that the use of the three sedatives, respectively, led to a marked increase in the levels of free radical indicators at 2 h after surgery, which then decreased at 24 h after surgery. Furthermore, lower levels of oxidative stress were found following the use of propofol and dexmedetomidine compared with those following midazolam administration, and similar results were obtained regarding the level of MN. It is suggested that propofol and dexmedetomidine exhibit a superior antioxidant function to midazolam. |
| Related Links | http://dx.doi.org/10.3892/etm.2015.2410 |
| Ending Page | 2298 |
| Page Count | 6 |
| Starting Page | 2293 |
| File Format | |
| ISSN | 17920981 |
| e-ISSN | 17921015 |
| Journal | Experimental and Therapeutic Medicine |
| Issue Number | 6 |
| Volume Number | 9 |
| Language | English |
| Publisher | D.A. Spandidos |
| Publisher Date | 2015-04-01 |
| Access Restriction | Open |
| Rights Holder | D.A. Spandidos |
| Subject Keyword | Immunology and Microbiology (miscellaneous) Cancer Research Medicine(all) Research in Higher Education |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cancer Research 2400/2401 |
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