Loading...
Please wait, while we are loading the content...
Similar Documents
Association of GSTP1 and XRCC1 gene polymorphisms with clinical outcome of advanced non-small cell lung cancer patients with cisplatin-based chemotherapy
| Content Provider | PubMed Central |
|---|---|
| Author | Han, Bateer Guo, Zhanlin Ma, Ying Kang, Shirong Wang, Yufei Wei, Qiyou Wu, Xu |
| Copyright Year | 2015 |
| Abstract | We investigated the association between the clinical outcome and GSTP1 and XRCC1 gene polymorphisms in advanced NSCLC patients with cisplatin-based chemotherapy. We prospectively recruited 325 NSCLC patients between January 2010 and January 2014. Genotypes of GSTP1 A313G, XRCC1 Arg194Trp, Arg280His and Arg399Gln were conducted using polymerase chain reaction restriction fragment length polymorphism (PCR-RFLP) assay. AG and GG genotypes of GSTP1 A313G were correlated with a higher CR + PR when compared with AA genotype. Furthermore, GA and AA genotypes of XRCC1 Arg399Gln were associated with more CR + PR when compared with GG genotype. In the Cox proportional hazards model, GG genotype of GSTP1 A313G was significantly correlated with a longer median survival time when compared with AA genotype, and it is associated with a heavy decreased risk of death from NSCLC. Moreover, GA and AA genotypes of XRCC1 Arg399Gln had a significantly longer median survival time, and GA and AA genotypes were significantly associated with a moderate reduced risk of death from NSCLC. GSTP1 A313G and XRCC1 Arg399Gln gene polymorphisms might influence the response to cisplatin-based chemotherapy and affect the clinical outcome of advanced NSCLC. |
| Ending Page | 4119 |
| Starting Page | 4113 |
| File Format | |
| ISSN | 19362625 |
| e-ISSN | 19362625 |
| Journal | International Journal of Clinical and Experimental Pathology |
| Issue Number | 4 |
| Volume Number | 8 |
| Language | English |
| Publisher | e-Century Publishing Corporation |
| Access Restriction | Open |
| Rights Holder | e-Century Publishing Corporation |
| Subject Keyword | Research in Higher Education |
| Content Type | Text |
| Resource Type | Article |
| Subject | Histology Pathology and Forensic Medicine |
