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| Content Provider | PubMed Central |
|---|---|
| Author | Niemirowicz, Katarzyna Prokop, Izabela Wilczewska, Agnieszka Z. Wnorowska, Urszula Piktel, Ewelina WÄ tek, Marzena Savage, Paul B. Bucki, Robert |
| Copyright Year | 2015 |
| Abstract | The pleiotropic activity of human cathelicidin LL-37 peptide includes an ability to suppress development of colon cancer cells. We hypothesized that the anticancer activity of LL-37 would improve when attached to the surface of magnetic nanoparticles (MNPs). Using colon cancer culture (DLD-1 cells and HT-29 cells), we evaluated the effects of MNPs, LL-37 peptide, its synthetic analog ceragenin CSA-13, and two novel nanosystems, ie, MNP@LL-37 and MNP@CSA-13, on cancer cell viability and apoptosis. Treatment of cancer cells with the LL-37 peptide linked to MNPs (MNP@LL-37) caused a greater decrease in cell viability and a higher rate of apoptosis compared with treatment using free LL-37 peptide. Additionally, we observed a strong ability of ceragenin CSA-13 and MNP@CSA-13 to induce apoptosis of DLD-1 cells. We found that both nanosystems were successfully internalized by HT-29 cells, and cathelicidin LL-37 and ceragenin CSA-13 might play a key role as novel homing molecules. These results indicate that the previously described anticancer activity of LL-37 peptide against colon cancer cells might be significantly improved using a theranostic approach. |
| Related Links | http://dx.doi.org/10.2147/ijn.s76104 |
| Ending Page | 3853 |
| Page Count | 11 |
| Starting Page | 3843 |
| File Format | |
| ISSN | 11782013 |
| e-ISSN | 11782013 |
| Journal | International Journal of Nanomedicine |
| Volume Number | 10 |
| Language | English |
| Publisher | Dove Medical Press |
| Publisher Date | 2015-06-01 |
| Access Restriction | Open |
| Rights Holder | Dove Medical Press |
| Subject Keyword | Research in Higher Education |
| Content Type | Text |
| Resource Type | Article |
| Subject | Nanoscience and Nanotechnology Organic Chemistry Medicine Drug Discovery Biomaterials Biophysics Bioengineering Pharmaceutical Science |
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