NDLI: Cell therapy from bench to bedside: Hepatocytes from fibroblasts - the truth and myth of transdifferentiation

Content Provider	PubMed Central
Author	Girija, Sanal Madhusudana
Copyright Year	2015
Abstract	Hepatocyte transplantation is an alternative to liver transplantation in certain disorders such as inherited liver diseases and liver failure. It is a relatively less complicated surgical procedure, and has the advantage that it can be repeated several times if unsuccessful. Another advantage is that hepatocytes can be isolated from partly damaged livers which are not suitable for liver transplantation. Despite these advantages hepatocyte transplantation is less popular. Important issues are poor engraftment of the transplanted cells and the scarcity of donor hepatocytes. Generation of “hepatocyte like cells”/iHeps from embryonic stem cells (ES) and induced pluripotent stem cells (iPSCs) by directed differentiation is an emerging solution to the latter issue. Direct conversation or trans-differentiation of fibroblasts to “hepatocyte like cells” is another way which is, being explored. However this method has several inherent and technical disadvantages compared to the directed differentiation from ES or iPSC. There are several methods claiming to be “highly efficient” for generating “highly functional” “hepatocyte like cells”. Currently different groups are working independently and coming up with differentiation protocols and each group claiming an advantage for their protocol. Directed differentiation protocols need to be designed, compared, analyzed and tweaked systematically and logically than empirically. There is a need for a well-coordinated global initiative comparable to the Human Genome Project to achieve this goal in the near future.
Related Links	http://dx.doi.org/10.3748/wjg.v21.i21.6427
Starting Page	6427
File Format	PDF
ISSN	10079327
e-ISSN	22192840
Journal	World Journal of Gastroenterology : WJG
Issue Number	21
Volume Number	21
Language	English
Publisher	Baishideng Publishing Group Inc
Publisher Date	2015-01-01
Access Restriction	Open
Rights Holder	Baishideng Publishing Group Inc
Subject Keyword	Gastroenterology Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Gastroenterology

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Cell Therapy From Bench to Bedside Translation in CNS Neurorestoratology Era

From Bedside to Bench: Reverse Engineering Medical Progress

Advances in treatment of ulcerative colitis with herbs: From bench to bedside

Mast Cells and Irritable Bowel Syndrome: From the Bench to the Bedside

Emerging hematological targets and therapy for cardiovascular disease: From bench to bedside

Ischaemia–reperfusion injury in liver transplantation—from bench to bedside

CAR-T Cell Therapy: From the Bench to the Bedside

An Update on Translating Stem Cell Therapy for Stroke from Bench to Bedside

Highlights of Keystone symposium ‘Fibrosis: from bench to bedside’

Cell therapy from bench to bedside: Hepatocytes from fibroblasts - the truth and myth of transdifferentiation

Similar Documents

Cell Therapy From Bench to Bedside Translation in CNS Neurorestoratology Era

From Bedside to Bench: Reverse Engineering Medical Progress

Advances in treatment of ulcerative colitis with herbs: From bench to bedside

Mast Cells and Irritable Bowel Syndrome: From the Bench to the Bedside

Emerging hematological targets and therapy for cardiovascular disease: From bench to bedside

Ischaemia–reperfusion injury in liver transplantation—from bench to bedside

CAR-T Cell Therapy: From the Bench to the Bedside

An Update on Translating Stem Cell Therapy for Stroke from Bench to Bedside

Highlights of Keystone symposium ‘Fibrosis: from bench to bedside’

Cell therapy from bench to bedside: Hepatocytes from fibroblasts - the truth and myth of transdifferentiation