NDLI: Contractile Units in Disordered Actomyosin Bundles Arise from F-Actin Buckling

Content Provider	PubMed Central
Author	Lenz, Martin Thoresen, Todd Gardel, Margaret L. Dinner, Aaron R.
Copyright Year	2012
Abstract	Bundles of filaments and motors are central to contractility in cells. The classic example is striated muscle, where actomyosin contractility is mediated by highly organized sarcomeres which act as fundamental contractile units. However, many contractile bundles in vivo and in vitro lack sarcomeric organization. Here we propose a model for how contractility can arise in bundles without sarcomeric organization and validate its predictions with experiments on a reconstituted system. In the model, internal stresses in frustrated arrangements of motors with diverse velocities cause filaments to buckle, leading to overall shortening. We describe the onset of buckling in the presence of stochastic motor head detachment and predict that buckling-induced contraction occurs in an intermediate range of motor densities. We then calculate the size of the “contractile units” associated with this process. Consistent with these results, our reconstituted actomyosin bundles show contraction at relatively high motor density, and we observe buckling at the predicted length scale.
Related Links	http://dx.doi.org/10.1103/physrevlett.108.238107
Ending Page	238107
Page Count	1
Starting Page	238107
File Format	PDF
ISSN	00319007
e-ISSN	10797114
Journal	Physical review letters
Issue Number	23
Volume Number	108
Language	English
Publisher Date	2012-06-01
Access Restriction	Open
Subject Keyword	Physics and Astronomy(all) Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Physics and Astronomy

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4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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