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| Content Provider | PubMed Central |
|---|---|
| Author | Bi, Shaojie Wang, Chunyan Jin, Yanwu Lv, Zhaopeng Xing, Xiaowei Lu, Qinghua |
| Copyright Year | 2015 |
| Abstract | Objective: To explore the correlation of miRNAs with clinical characteristics of ACS. Methods: 50 ACS patients and 50 healthy controls were randomly selected. On the basis of miRNA expression levels, ACS patients were classified as low miRNA expression group (fold change: <3) and high miRNA expression group (≥3). Results: miR-208a expression increased markedly in the serum exosomes of ACS patients, and miR-208a expression in the serum of ACS patients was also significantly higher than that in healthy controls. However, the sensitivity of serum miR-208a was inferior to that of exosome miR-208a. Analysis of clinical characteristics showed the mean age of 500 ACS patients was 62.35±9.70 years, and there were 300 patients in low miR-208a expression group and 200 patients in high miR-208a expression group. When compared with low miR-208a expression group, patients with high miR-208a expression were older, and had higher Killip class, higher CK-MB peak, higher cTnT peak and elevated LDL (P<0.05). Within 1-year follow up, 32 patients died including 10 in low miR-208a expression group with the mortality of 3.3% and 22 in high miR-208a expression group with the mortality of 11.0%. Kaplan-Meier survival analysis revealed that the 1-year survival rate reduced significantly in patients with high miR-208a expression. Conclusion: miRNA-208a expression is significantly up-regulated in the serum exosomes of ACS patients and is crucial for the diagnosis of ACS. |
| Ending Page | 4280 |
| Starting Page | 4275 |
| File Format | |
| ISSN | 19405901 |
| e-ISSN | 19405901 |
| Journal | International Journal of Clinical and Experimental Medicine |
| Issue Number | 3 |
| Volume Number | 8 |
| Language | English |
| Publisher | e-Century Publishing Corporation |
| Publisher Date | 2015-03-15 |
| Access Restriction | Open |
| Rights Holder | e-Century Publishing Corporation |
| Subject Keyword | Research in Higher Education |
| Content Type | Text |
| Resource Type | Article |
| Subject | Biochemistry, Genetics and Molecular Biology |
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