NDLI: Novel anthropomorphic hip phantom corrects systemic interscanner differences in proximal femoral vBMD

Content Provider	PubMed Central
Author	Bonaretti, S. Carpenter, R. D. Burghardt, A. J. Yu, L. Bruesewitz, M. Khosla, S. Lang, T. Saeed, I.
Abstract	Quantitative computed tomography (QCT) is increasingly used in osteoporosis studies to assess volumetric bone mineral density (vBMD), bone quality and strength. However, QCT is confronted by technical issues in the clinical research setting, such as potentially confounding effects of body size on vBMD measurements and lack of standard approaches to scanner cross-calibration, which affects measurements of vBMD in multicenter settings. In this study, we addressed systematic inter-scanner differences and subject-dependent body size errors using a novel anthropomorphic hip phantom, containing a calibration hip to estimate correction equations, and a contralateral test hip to assess the quality of the correction. We scanned this phantom on four different scanners and we applied phantom-derived corrections to in-vivo images of 16 postmenopausal women scanned on two scanners. From the phantom study, we found that vBMD decreased with increasing phantom size in three of four scanners and that inter-scanner variations increased with increasing phantom size. In the in vivo study, we observed that inter-scanner corrections reduced systematic inter-scanner mean vBMD differences but that the inter-scanner precision error was still larger than expected from known intra-scanner precision measurements. In conclusion, inter-scanner corrections and body size influence should be considered when measuring vBMD from QCT images.
Related Links	http://dx.doi.org/10.1088/0031-9155/59/24/7819
Ending Page	7834
Page Count	16
Starting Page	7819
File Format	PDF
ISSN	00319155
e-ISSN	13616560
Journal	Physics in medicine and biology
Issue Number	24
Volume Number	59
Language	English
Publisher Date	2014-12-21
Access Restriction	Open
Subject Keyword	Radiological and Ultrasound Technology Radiology Nuclear Medicine and imaging Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Radiology, Nuclear Medicine and Imaging Radiological and Ultrasound Technology

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1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
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3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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