NDLI: Metal Zn(II), Cu(II), Ni (II) complexes of ursodeoxycholic acid as putative anticancer agents

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Metal Zn(II), Cu(II), Ni (II) complexes of ursodeoxycholic acid as putative anticancer agents

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Year: 2014, Volume: 28, Issue: 2

Year: 2014, Volume: 28, Issue: 1

Metal Zn(II), Cu(II), Ni (II) complexes of ursodeoxycholic acid as putative anticancer agents

Content Provider	PubMed Central
Author	Dyakova, Lora Culita, Daniela-cristina Marinescu, Gabriela Alexandrov, Marin Kalfin, Reni Patron, Luminita Alexandrova, Radostina
Copyright Year	2014
Abstract	The aim of the study was to evaluate the influence of metal [Zn(II), Cu(II), Ni(II)] complexes with ursodeoxycholic acid (UDCA) on the viability and proliferation of tumour and non-tumour cells. Cell lines established from retrovirus-transformed chicken hepatoma (LSCC-SF-Mc29) and rat sarcoma (LSR-SF-SR) as well as from human cancers of the breast (MCF-7), uterine cervix (HeLa), lung (A549) and liver (HepG2) were used as model systems. Non-tumour human embryo (Lep-3) cells were also included in some of the experiments. The investigations were carried out by the thiazolyl blue tetrazolium bromide (MTT) test, neutral red uptake cytotoxicity assay, crystal violet staining, double staining with acridine orange and propidium iodide and the colony-forming method. The results obtained revealed that: (1) UDCA and its metal complexes in the tested concentrations decreased (to a varying degree) the viability and proliferation of the treated cells in a time- and concentration-dependent manner; (2) chicken hepatoma (LSCC-SF-Mc29) cells were most sensitive to the cytotoxic and antiproliferative action of the compounds tested, followed by rat sarcoma (LSR-SF-SR) cells; (3) Cu‒UDCA and Ni‒UDCA were more effective against animal LSCC-SF-Mc29 and LSR-SF-SR cells, while Zn‒UDCA significantly decreased the viability and proliferation of human tumour cell lines; (4) applied independently, UDCA expressed lower cytotoxic/cytostatic activity as compared to metal complexes; and (5) the sensitivity of the non-tumour embryonic Lep-3 cells to the effects of UDCA and its metal complexes was comparable or even higher than those of the human tumour cells.
Related Links	http://dx.doi.org/10.1080/13102818.2014.927973
Ending Page	551
Page Count	9
Starting Page	543
File Format	PDF
ISSN	13102818
e-ISSN	13143530
Journal	Biotechnology, Biotechnological Equipment
Issue Number	3
Volume Number	28
Language	English
Publisher	Taylor & Francis
Publisher Date	2014-05-04
Access Restriction	Open
Rights Holder	Taylor & Francis
Subject Keyword	Biotechnology Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Biotechnology

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