NDLI: High-fat diet induced obesity primes inflammation in adipose tissue prior to liver in C57BL/6j mice

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High-fat diet induced obesity primes inflammation in adipose tissue prior to liver in C57BL/6j mice

Content Provider	PubMed Central
Author	Heijden, Roel A. Van Der Sheedfar, Fareeba Morrison, Martine C. Hommelberg, Pascal Ph Kor, Danny Kloosterhuis, Niels J. Gruben, Nanda Youssef, Sameh A. Bruin, Alain De Hofker, Marten H. Kleemann, Robert Koonen, Debby Py Heeringa, Peter
Copyright Year	2015
Abstract	Metabolic inflammation in adipose tissue and the liver is frequently observed as a result of diet-induced obesity in human and rodent studies. Although the adipose tissue and the liver are both prone to become chronically inflamed with prolonged obesity, their individual contribution to the development of metabolic inflammation remains speculative. Thus, we aimed to elucidate the sequence of inflammatory events in adipose and hepatic tissues to determine their contribution to the development of metabolic inflammation and insulin resistance (IR) in diet-induced obesity. To confirm our hypothesis that adipose tissue (AT) inflammation is initiated prior to hepatic inflammation, C57BL/6J male mice were fed a low-fat diet (LFD; 10% kcal fat) or high-fat diet (HFD; 45% kcal fat) for either 24, 40 or 52 weeks. Lipid accumulation and inflammation was measured in AT and liver. Glucose tolerance was assessed and plasma levels of glucose, insulin, leptin and adiponectin were measured at various time points throughout the study. With HFD, C57BL/6j mice developed a progressive obese phenotype, accompanied by IR at 24 and 40 weeks of HFD, but IR was attenuated after 52 weeks of HFD. AT inflammation was present after 24 weeks of HFD, as indicated by the increased presence of crown-like structures and up-regulation of pro-inflammatory genes Tnf, Il1β, Mcp1 and F4/80. As hepatic inflammation was not detected until 40 weeks of HFD, we show that AT inflammation is established prior to the development of hepatic inflammation. Thus, AT inflammation is likely to have a greater contribution to the development of IR compared to hepatic inflammation.
Ending Page	267
Starting Page	256
File Format	PDF
ISSN	19454589
e-ISSN	19454589
Journal	Aging (Albany NY)
Issue Number	4
Volume Number	7
Language	English
Publisher	Impact Journals LLC
Publisher Date	2015-04-23
Access Restriction	Open
Rights Holder	Impact Journals LLC
Subject Keyword	Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Cell Biology Aging

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