NDLI: Gold(III)–pyrrolidinedithiocarbamato Derivatives as Antineoplastic Agents**

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Cover Picture: Sol-Gel Microspheres Doped with Glycerol: A Structural Insight in Light of Forthcoming Applications in the Polyurethane Foam Industry (ChemistryOpen 2/2015)

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Gold(III)–pyrrolidinedithiocarbamato Derivatives as Antineoplastic Agents**

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Year: 2015, Volume: 4, Issue: 1

Year: 2014, Volume: 3

Year: 2013, Volume: 2

Year: 2012, Volume: 1

Gold(III)–pyrrolidinedithiocarbamato Derivatives as Antineoplastic Agents**

Content Provider	PubMed Central
Author	Nardon, Chiara Chiara, Federica Leonardo, Brustolin Alberto, Gambalunga Francesco, Ciscato Andrea, Rasola Trevisan, Andrea Dolores, Fregona
Copyright Year	2014
Abstract	Transition metals offer many possibilities in developing potent chemotherapeutic agents. They are endowed with a variety of oxidation states, allowing for the selection of their coordination numbers and geometries via the choice of proper ligands, leading to the tuning of their final biological properties. We report here on the synthesis, physico-chemical characterization, and solution behavior of two gold(III) pyrrolidinedithiocarbamates (PDT), namely [AuIIIBr2(PDT)] and [AuIIICl2(PDT)]. We found that the bromide derivative was more effective than the chloride one in inducing cell death for several cancer cell lines. [AuIIIBr2(PDT)] elicited oxidative stress with effects on the permeability transition pore, a mitochondrial channel whose opening leads to cell death. More efficient antineoplastic strategies are required for the widespread burden that is cancer. In line with this, our results indicate that [AuIIIBr2(PDT)] is a promising antineoplastic agent that targets cellular components with crucial functions for the survival of tumor cells.
Related Links	http://dx.doi.org/10.1002/open.201402091
Starting Page	183
File Format	PDF
ISSN	21911363
e-ISSN	21911363
Journal	ChemistryOpen
Issue Number	2
Volume Number	4
Language	English
Publisher	BlackWell Publishing Ltd
Publisher Date	2015-04-01
Access Restriction	Open
Rights Holder	BlackWell Publishing Ltd
Subject Keyword	Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Chemistry

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