NDLI: Lymphoid Fibrosis Occurs in Long-Term Nonprogressors and Persists With Antiretroviral Therapy but May Be Reversible With Curative Interventions

Content Provider	PubMed Central
Author	Sanchez, Joyce L. Hunt, Peter W. Reilly, Cavan S. Hatano, Hiroyu Beilman, Gregory J. Alexander, Khoruts Jasurda, Jake S. Somsouk, Ma Thorkelson, Ann Russ, Samuel Anderson, Jodi Deeks, Steven G. Schacker, Timothy W.
Copyright Year	2014
Abstract	Human immunodeficiency virus (HIV) replication causes lymphoid tissue (LT) fibrosis, which causes CD4+ T-cell depletion. It is unknown whether people who spontaneously control HIV replication have LT fibrosis. We measured LT fibrosis and CD4+ T cells in 25 HIV controllers, 10 noncontrollers, 45 HIV-positive individuals receiving therapy, and 10 HIV-negative individuals. Controllers had significant LT fibrosis and CD4+ T-cell depletion, similar to noncontrollers, but the so-called Berlin patient (in whom HIV infection was cured) had near normal LT. Thus, LT fibrosis occurs in all HIV-infected subjects, and current therapy does not reverse it. Reversal of fibrosis during a curative intervention suggests that ongoing low-level virus production may maintain LT fibrosis.
Related Links	http://dx.doi.org/10.1093/infdis/jiu586
Ending Page	1075
Page Count	8
Starting Page	1068
File Format	PDF
ISSN	00221899
e-ISSN	15376613
Journal	The Journal of Infectious Diseases
Issue Number	7
Volume Number	211
Language	English
Publisher	Oxford University Press
Publisher Date	2015-04-01
Access Restriction	Open
Rights Holder	Oxford University Press
Subject Keyword	Immunology and Allergy Infectious Diseases Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Infectious Diseases Immunology and Allergy

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