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| Content Provider | PubMed Central |
|---|---|
| Author | Jurczak, Anna Szkup, Małgorzata Samochowiec, Agnieszka Grzywacz, Anna Samochowiec, Jerzy Beata, Karakiewicz Barbara, Dołęgowska Grochans, Elżbieta |
| Editor | Tchounwou, Paul B. |
| Copyright Year | 2015 |
| Abstract | Background: The aim of this study was to analyze the influence of genetic and hormonal factors on incidences of depressive symptoms in late-reproductive-age women. Methods: The study was performed using the Beck Depression Inventory, the PCR, and genetic tests of 347 healthy late-reproductive-age Polish women. Results: The relationship between the level of anti-Müllerian hormone (AMH) and depressive symptoms was not statistically significant (p > 0.05). Increases in age and FSH levels were accompanied by a decrease in AMH level in a significant way (p < 0.05). There were no statistically significant relationships between the distribution of genotypes and the frequency of alleles of the investigated polymorphisms and depressive symptoms according to the Beck Depression Inventory. Conclusions: (1) The presence of the s/s genotype of the 5-HTTLPR polymorphism in the serotonin transporter promoter region and the 3/3 genotype of the 30-bp VNTR polymorphism in the monoamine oxidase A promoter region does not contribute to the development of depressive symptoms in late-reproductive-age women. (2) A relationship between the level of anti-Müllerian hormone and depressive symptoms was not confirmed in the group of healthy late-reproductive-age women. (3) AMH level correlates negatively with FSH level and age, which confirms that AMH can be regarded as a factor reflecting the ovarian reserve. |
| Related Links | http://dx.doi.org/10.3390/ijerph120403547 |
| Ending Page | 3563 |
| Page Count | 17 |
| Starting Page | 3547 |
| File Format | |
| ISSN | 16604601 |
| e-ISSN | 16604601 |
| Journal | International Journal of Environmental Research and Public Health |
| Issue Number | 4 |
| Volume Number | 12 |
| Language | English |
| Publisher | MDPI |
| Publisher Date | 2015-03-01 |
| Access Restriction | Open |
| Rights Holder | MDPI |
| Subject Keyword | Research in Higher Education |
| Content Type | Text |
| Resource Type | Article |
| Subject | Health, Toxicology and Mutagenesis Pollution Public Health, Environmental and Occupational Health |
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