NDLI: Bisphenol A and phthalate metabolite urinary concentrations: Daily and across pregnancy variability

Content Provider	PubMed Central
Author	Fisher, Mandy Arbuckle, Tye E. Mallick, Ranjeeta Leblanc, Alain Hauser, Russ Feeley, Mark Diane, Koniecki Ramsay, Tim Provencher, Gilles Bérubé, René Walker, Mark
Copyright Year	2015
Abstract	Phthalates and bisphenol A (BPA) are high production volume and ubiquitous chemicals that are quickly metabolized in the body. Traditionally, studies have relied on single spot urine analyses to assess exposure; ignoring variability in concentrations throughout a day or over a longer period of time. We compared BPA and phthalate metabolite results from urine samples collected at five different time points. Participants (n=80) were asked to collect all voids in a 24 h period on a weekday and then again on a weekend before 20 weeks of pregnancy. During the second and third trimesters and in the postpartum period, single spot urines were collected. Variability over time in urinary concentrations was assessed using intraclass correlation coefficients (ICCs) and the sensitivity to correctly classify a single sample as high or low versus the geometric mean (GM) of all samples was calculated. We found low reproducibility and sensitivity of BPA and all phthalate metabolites throughout pregnancy and into the postpartum period but much higher reproducibility within a day. Time of day when the urine was collected was a significant predictor of specific gravity adjusted exposure levels. We concluded that, if the interest is in average exposures across pregnancy, maternal/fetal exposure estimation may be more accurate if multiple measurements, collected across the course of the entire pregnancy, rather than a single spot measure, are performed.
Related Links	http://dx.doi.org/10.1038/jes.2014.65
Ending Page	239
Page Count	9
Starting Page	231
File Format	PDF
ISSN	15590631
e-ISSN	1559064X
Journal	Journal of Exposure Science & Environmental Epidemiology
Issue Number	3
Volume Number	25
Language	English
Publisher	Nature Publishing Group
Publisher Date	2015-05-01
Access Restriction	Open
Rights Holder	Nature Publishing Group
Subject Keyword	Toxicology Public Health, Environmental and Occupational Health Epidemiology Pollution Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Pollution Public Health, Environmental and Occupational Health Toxicology Epidemiology

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Variability of Urinary Phthalate Metabolite and Bisphenol A Concentrations before and during Pregnancy

Bisphenol A and phthalate metabolite urinary concentrations: Daily and across pregnancy variability.

Erratum: Braun et al. “Variability of Urinary Phthalate Metabolite and Bisphenol A Concentrations before and during Pregnancy” [120:739–745 (2012)]

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Bisphenol A and phthalate metabolite urinary concentrations: Daily and across pregnancy variability

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