NDLI: Unsaturated fatty acids induce non-canonical autophagy

Content Provider	PubMed Central
Author	Niso-santano, Mireia Malik, Shoaib Ahmad Federico, Pietrocola Pedro, José Manuel Bravo-san Mariño, Guillermo Cianfanelli, Valentina Ben-younès, Amena Troncoso, Rodrigo Maria, Markaki Sica, Valentina Izzo, Valentina Chaba, Kariman Chantal, Bauvy Dupont, Nicolas Kepp, Oliver Rockenfeller, Patrick Wolinski, Heimo Madeo, Frank Lavandero, Sergio Patrice, Codogno Harper, Francis Pierron, Gérard Tavernarakis, Nektarios Cecconi, Francesco Maiuri, Maria Chiara Galluzzi, Lorenzo Kroemer, Guido
Copyright Year	2015
Abstract	To obtain mechanistic insights into the cross talk between lipolysis and autophagy, two key metabolic responses to starvation, we screened the autophagy-inducing potential of a panel of fatty acids in human cancer cells. Both saturated and unsaturated fatty acids such as palmitate and oleate, respectively, triggered autophagy, but the underlying molecular mechanisms differed. Oleate, but not palmitate, stimulated an autophagic response that required an intact Golgi apparatus. Conversely, autophagy triggered by palmitate, but not oleate, required AMPK, PKR and JNK1 and involved the activation of the BECN1/PIK3C3 lipid kinase complex. Accordingly, the downregulation of BECN1 and PIK3C3 abolished palmitate-induced, but not oleate-induced, autophagy in human cancer cells. Moreover, Becn1 +/− mice as well as yeast cells and nematodes lacking the ortholog of human BECN1 mounted an autophagic response to oleate, but not palmitate. Thus, unsaturated fatty acids induce a non-canonical, phylogenetically conserved, autophagic response that in mammalian cells relies on the Golgi apparatus.
Related Links	http://dx.doi.org/10.15252/embj.201489363
Ending Page	1041
Page Count	17
Starting Page	1025
File Format	PDF
ISSN	02614189
e-ISSN	14602075
Journal	The EMBO Journal
Issue Number	8
Volume Number	34
Language	English
Publisher	BlackWell Publishing Ltd
Publisher Date	2015-04-15
Access Restriction	Open
Rights Holder	BlackWell Publishing Ltd
Subject Keyword	Biochemistry, Genetics and Molecular Biology(all) Immunology and Microbiology(all) Neuroscience(all) Molecular Biology Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Neuroscience Immunology and Microbiology Medicine Molecular Biology

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1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
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9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

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