NDLI: Alterations of serum brain type natriuretic peptide (BNP) in patients with Crimean-Congo hemorrhagic fever

Content Provider	PubMed Central
Author	Uysal, Elif Bilge Enver, Sancakdar Şeker, Ayşe Deveci, Köksal Tuzcu, Nevin Karapınar, Hekim
Copyright Year	2015
Abstract	Background: Crimean-Congo hemorrhagic fever (CCHF) is known to be associated with cardiac damage. Brain type natriuretic peptide (BNP) is secreted from stressed myocardium. Objectives: This study investigated that BNP levels in CCHF and its association with clinical course of disease. Methods: Consecutive CCHF diagnosis confirmed patients were enrolled to the study. Results of patients were compared with age-sex-matched healthy volunteers. Blood samples for BNP levels were collected from the patients during emergency room applications. Mortality, hospitalization duration and other disease severity predictors (thrombocyte count, hemoglobin, white blood cell count, alanine aminotransferase, aspartate aminotransferase, prothrombin time, lactate dehydrogenase, international normalized ratio, activated partial thromboplastin time) were recorded. These parameters’ correlations with BNP levels were analyzed. Result: Forty-three CCHF patients and 28 control subjects recruited to the study. Groups were similar for age and gender. There was no mortality. Levels of BNP were found to be significantly higher in patients than control subjects (100.4±45.4 vs. 78.0±40.4, P=0.033). But BNP levels were not correlated with duration of hospitalization and disease severity predictors (P > 0.05). Conclusions: This study showed that BNP levels are modestly increased in CCHF but this increase does not correlated with disease severity predictors.
Ending Page	2788
Starting Page	2784
File Format	PDF
ISSN	19405901
e-ISSN	19405901
Journal	International Journal of Clinical and Experimental Medicine
Issue Number	2
Volume Number	8
Language	English
Publisher	e-Century Publishing Corporation
Publisher Date	2015-02-15
Access Restriction	Open
Rights Holder	e-Century Publishing Corporation
Subject Keyword	Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Biochemistry, Genetics and Molecular Biology

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