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| Content Provider | PubMed Central |
|---|---|
| Author | Munaf, Aal-aaboda Alhaddad, Hasan Francis, Osowik Nauli, Surya M. Sari, Youssef |
| Abstract | Alcohol consumption is largely associated with alterations in the extracellular glutamate concentrations in several brain reward regions. We have recently found that glutamate transporter 1 (GLT-1) is downregulated following chronic exposure to ethanol for five weeks in alcohol-preferring rats, and upregulation of the GLT-1 levels in nucleus accumbens and prefrontal cortex resulted, in part, in attenuating ethanol consumption. Cysteine glutamate antiporter (xCT) was also found to be downregulated after chronic ethanol exposure in P rats, and its upregulation could be valuable in attenuating ethanol drinking. In this study, we examined the effect of a synthetic compound, (R)-(−)-5-methyl-1-nicotinoyl-2-pyrazoline (MS-153), on ethanol drinking and expression of GLT-1 and xCT in the amygdala and hippocampus of P rats. P rats were exposed to continuous free-choice access to water, 15% and 30% ethanol, and food for five weeks, and then after which they received treatments of MS-153 or vehicle for five days. The results showed that MS-153 treatment significantly reduced ethanol consumption in P rats. It was revealed that GLT-1 and xCT expressions were downregulated in both the amygdala and hippocampus of ethanol-vehicle treated rats (ethanol vehicle group) as compared to water control animals. Importantly, MS-153 treatment upregulated GLT-1 and xCT expression in these brain regions. These findings provide important role of MS-153 on these glutamate transporters for the attenuation of ethanol drinking behavior. |
| Related Links | http://dx.doi.org/10.1002/jnr.23554 |
| Ending Page | 937 |
| Page Count | 8 |
| Starting Page | 930 |
| File Format | |
| ISSN | 03604012 |
| e-ISSN | 10974547 |
| Journal | Journal of neuroscience research |
| Issue Number | 6 |
| Volume Number | 93 |
| Language | English |
| Publisher Date | 2015-06-01 |
| Access Restriction | Open |
| Subject Keyword | Cellular and Molecular Neuroscience Research in Higher Education |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cellular and Molecular Neuroscience |
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