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| Content Provider | PubMed Central |
|---|---|
| Author | Bai, Xuelian Kim, Tae Im Lee, Ji-yun Dai, Fuhong Hong, Sung-jong |
| Copyright Year | 2015 |
| Abstract | Clonorchis sinensis habitating in the bile duct of mammals causes clonorchiasis endemic in East Asian countries. Parkin is a RING-between-RING protein and has E3-ubiquitin ligase activity catalyzing ubiquitination and degradation of substrate proteins. A cDNA clone of C. sinensis was predicted to encode a polypeptide homologous to parkin (CsParkin) including 5 domains (Ubl, RING0, RING1, IBR, and RING2). The cysteine and histidine residues binding to Zn2+ were all conserved and participated in formation of tertiary structural RINGs. Conserved residues were also an E2-binding site in RING1 domain and a catalytic cysteine residue in the RING2 domain. Native CsParkin was determined to have an estimated molecular weight of 45.7 kDa from C. sinensis adults by immunoblotting. CsParkin revealed E3-ubiquitin ligase activity and higher expression in metacercariae than in adults. CsParkin was localized in the locomotive and male reproductive organs of C. sinensis adults, and extensively in metacercariae. Parkin has been found to participate in regulating mitochondrial function and energy metabolism in mammalian cells. From these results, it is suggested that CsParkin play roles in energy metabolism of the locomotive organs, and possibly in protein metabolism of the reproductive organs of C. sinensis. |
| Related Links | http://dx.doi.org/10.3347/kjp.2015.53.1.65 |
| Ending Page | 75 |
| Page Count | 11 |
| Starting Page | 65 |
| File Format | |
| ISSN | 00234001 |
| e-ISSN | 17380006 |
| Journal | The Korean Journal of Parasitology |
| Issue Number | 1 |
| Volume Number | 53 |
| Language | English |
| Publisher | The Korean Society for Parasitology and Tropical Medicine |
| Publisher Date | 2015-02-01 |
| Access Restriction | Open |
| Rights Holder | The Korean Society for Parasitology and Tropical Medicine |
| Subject Keyword | Parasitology Infectious Diseases Research in Higher Education |
| Content Type | Text |
| Resource Type | Article |
| Subject | Infectious Diseases Parasitology |
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