NDLI: PI(4,5)P2-binding effector proteins for vesicle exocytosis

Content Provider	PubMed Central
Author	Martin, Thomas F. J.
Copyright Year	2014
Abstract	PI(4,5)P2 participates directly in priming and possibly fusion steps of Ca2+-triggered vesicle exocytosis. High concentration nanodomains of PI(4,5)P2 reside on the plasma membrane of neuroendocrine cells. A subset of vesicles that co-localize with PI(4,5)P2 domains appear to undergo preferential exocytosis in stimulated cells. PI(4,5)P2 directly regulates vesicle exocytosis by recruiting and activating PI(4,5)P2-binding proteins that regulate SNARE protein function including CAPS, Munc13-1/2, synaptotagmin-1, and other C2 domain-containing proteins. These PI(4,5)P2 effector proteins are coincidence detectors that engage in multiple interactions at vesicle exocytic sites. The SNARE protein syntaxin-1 also binds to PI(4,5)P2, which promotes clustering, but an activating role for PI(4,5)P2 in syntaxin-1 function remains to be fully characterized. Similar principles underlie polarized constitutive vesicle fusion mediated in part by the PI(4,5)P2-binding subunits of the exocyst complex (Sec3, Exo70). Overall, focal vesicle exocytosis occurs at sites landmarked by PI(4,5)P2, which serves to recruit and/or activate multifunctional PI(4,5)P2-binding proteins.
Related Links	http://dx.doi.org/10.1016/j.bbalip.2014.09.017
Ending Page	793
Page Count	9
Starting Page	785
File Format	PDF
ISSN	13881981
Journal	Biochimica et biophysica acta
Issue Number	6
Volume Number	1851
Language	English
Publisher Date	2015-06-01
Access Restriction	Open
Subject Keyword	Cell Biology Molecular Biology Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Cell Biology Molecular Biology

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PI(4,5)P2-binding effector proteins for vesicle exocytosis.

Role of PI(4,5)P2 in Vesicle Exocytosis and Membrane Fusion

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PI(4,5)P2-binding effector proteins for vesicle exocytosis.

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