NDLI: eNanoMapper: harnessing ontologies to enable data integration for nanomaterial risk assessment

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eNanoMapper: harnessing ontologies to enable data integration for nanomaterial risk assessment

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eNanoMapper: harnessing ontologies to enable data integration for nanomaterial risk assessment

Content Provider	PubMed Central
Author	Hastings, Janna Nina, Jeliazkova Owen, Gareth Georgia, Tsiliki Munteanu, Cristian R. Steinbeck, Christoph Willighagen, Egon
Abstract	Engineered nanomaterials (ENMs) are being developed to meet specific application needs in diverse domains across the engineering and biomedical sciences (e.g. drug delivery). However, accompanying the exciting proliferation of novel nanomaterials is a challenging race to understand and predict their possibly detrimental effects on human health and the environment. The eNanoMapper project (www.enanomapper.net) is creating a pan-European computational infrastructure for toxicological data management for ENMs, based on semantic web standards and ontologies. Here, we describe the development of the eNanoMapper ontology based on adopting and extending existing ontologies of relevance for the nanosafety domain. The resulting eNanoMapper ontology is available at http://purl.enanomapper.net/onto/enanomapper.owl. We aim to make the re-use of external ontology content seamless and thus we have developed a library to automate the extraction of subsets of ontology content and the assembly of the subsets into an integrated whole. The library is available (open source) at http://github.com/enanomapper/slimmer/. Finally, we give a comprehensive survey of the domain content and identify gap areas. ENM safety is at the boundary between engineering and the life sciences, and at the boundary between molecular granularity and bulk granularity. This creates challenges for the definition of key entities in the domain, which we also discuss.
Related Links	http://dx.doi.org/10.1186/s13326-015-0005-5
Starting Page	10
File Format	PDF
ISSN	20411480
e-ISSN	20411480
Journal	Journal of Biomedical Semantics
Volume Number	6
Language	English
Publisher	BioMed Central
Publisher Date	2015-12-01
Access Restriction	Open
Rights Holder	BioMed Central
Subject Keyword	Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Computer Networks and Communications Information Systems Health Informatics Computer Science Applications

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