NDLI: Highly specific role of the insulin receptor in breast cancer progression

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Highly specific role of the insulin receptor in breast cancer progression

Content Provider	PubMed Central
Author	Ran, Rostoker Abelson, Sagi Keren, Bitton-worms Genkin, Inna Ben-shmuel, Sarit Maria, Dakwar Orr, Zila Shen Caspi, Avishay Tzukerman, Maty Leroith, Derek
Copyright Year	2015
Abstract	Accumulating evidence from clinical trials indicates that specific targeting of the IGF1 receptor (IGF1R) is not efficient as an anti-breast cancer treatment. One possible reason is that the mitogenic signals from the insulin receptor (IR) can be processed independently or as compensation to inhibition of the IGF1R. In this study, we highlight the role of the IR in mediating breast tumor progression in both WT mice and a hyperinsulinemic MKR mouse model by induction of Ir (Insr) or Igf1r knockdown (KD) in the mammary carcinoma Mvt-1 cell line. By using the specific IR antagonist-S961, we demonstrated that Igf1r-KD induces elevated responses by the IR to IGF1. On the other hand, Ir-KD cells generated significantly smaller tumors in the mammary fat pads of both WT and MKR mice, as opposed to control cells, where as the Igf1r-KD cells did not. The tumorigenic effects of insulin on the Mvt-1 cells were also demonstrated using microarray analysis, which indicates alteration of genes and signaling pathways involved in proliferation, the cell cycle, and apoptosis following insulin stimulation. In addition, the correlation between IR and the potential prognostic marker for aggressive breast cancer, CD24, was examined in the Ir-KD cells. Fluorescence-activated cell sorting (FACS) analysis revealed more than 60% reduction in CD24 expression in the Ir-KD cells when compared with the control cells. Our results also indicate that CD24-expressing cells can restore, at least in part, the tumorigenic capacity of Ir-KD cells. Taken together, our results highlight the mitogenic role of the IR in mammary tumor progression with a direct link to CD24 expression.
Related Links	http://dx.doi.org/10.1530/erc-14-0490
Ending Page	157
Page Count	13
Starting Page	145
File Format	PDF
ISSN	13510088
e-ISSN	14796821
Journal	Endocrine-related cancer
Issue Number	2
Volume Number	22
Language	English
Publisher Date	2015-02-18
Access Restriction	Open
Subject Keyword	Cancer Research Oncology Endocrinology, Diabetes and Metabolism Endocrinology Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Endocrinology, Diabetes and Metabolism Cancer Research Endocrinology Oncology

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