NDLI: Insulin signaling is acutely required for long-term memory in Drosophila

Content Provider	PubMed Central
Author	Chambers, Daniel B. Alaura, Androschuk Rosenfelt, Cory Langer, Steven Harding, Mark Bolduc, Francois V.
Copyright Year	2015
Abstract	Memory formation has been shown recently to be dependent on energy status in Drosophila. A well-established energy sensor is the insulin signaling (InS) pathway. Previous studies in various animal models including human have revealed the role of insulin levels in short-term memory but its role in long-term memory remains less clear. We therefore investigated genetically the spatial and temporal role of InS using the olfactory learning and long-term memory model in Drosophila. We found that InS is involved in both learning and memory. InS in the mushroom body is required for learning and long-term memory whereas long-term memory specifically is impaired after InS signaling disruption in the ellipsoid body, where it regulates the level of p70s6k, a downstream target of InS and a marker of protein synthesis. Finally, we show also that InS is acutely required for long-term memory formation in adult flies.
Related Links	http://dx.doi.org/10.3389/fncir.2015.00008
Starting Page	8
File Format	PDF
ISSN	16625110
e-ISSN	16625110
Journal	Frontiers in Neural Circuits
Volume Number	9
Language	English
Publisher	Frontiers Media S.A.
Publisher Date	2015-03-01
Access Restriction	Open
Rights Holder	Frontiers Media S.A.
Subject Keyword	Sensory Systems Cognitive Neuroscience Cellular and Molecular Neuroscience Neuroscience (miscellaneous) Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Cognitive Neuroscience Sensory Systems Cellular and Molecular Neuroscience

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