NDLI: Reciprocal Interareal Connections to Corticospinal Neurons in Mouse M1 and S2

Content Provider	PubMed Central
Author	Suter, Benjamin A. Shepherd, Gordon M. G.
Copyright Year	2015
Abstract	Primary motor (M1) and secondary somatosensory (S2) cortices, although anatomically and functionally distinct, share an intriguing cellular component: corticospinal neurons (CSP) in layer 5B. Here, we investigated the long-range circuits of CSPs in mouse forelimb-M1 and S2. We found that interareal projections (S2 → M1 and M1 → S2) monosynaptically excited pyramidal neurons across multiple layers, including CSPs. Area-specific differences were observed in the relative strengths of inputs to subsets of CSPs and other cell types, but the general patterns were similar. Furthermore, subcellular mapping of the dendritic distributions of these corticocortical excitatory synapses onto CSPs in both areas also showed similar patterns. Because layer 5B is particularly thick in M1, but not S2, we studied M1-CSPs at different cortical depths, quantifying their dendritic morphology and mapping inputs from additional cortical (M2, contralateral M1, and local layer 2/3) and thalamic (VL nucleus) sources. These results indicated that CSPs exhibit area-specific modifications on an otherwise conserved synaptic organization, and that different afferents innervate M1-CSP dendritic domains in a source-specific manner. In the cervical spinal cord, CSP axons from S2 and M1 partly converged on middle layers, but S2-CSP axons extended further dorsally, and M1-CSP axons ventrally. Thus, our findings identify many shared features in the circuits of M1 and S2 and show that these areas communicate via mutual projections that give each area monosynaptic access to the other area's CSPs. These interareally yoked CSP circuits may enable M1 and S2 to operate in a coordinated yet differentiated manner in the service of sensorimotor integration.
Related Links	http://dx.doi.org/10.1523/JNEUROSCI.4287-14.2015
Ending Page	2974
Page Count	16
Starting Page	2959
File Format	PDF
ISSN	15292401
e-ISSN	15292401
Journal	The Journal of Neuroscience
Issue Number	7
Volume Number	35
Language	English
Publisher	Society for Neuroscience
Publisher Date	2015-02-18
Access Restriction	Open
Rights Holder	Society for Neuroscience
Subject Keyword	Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Neuroscience

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

The activity of M1 corticospinal neurons during tool use by macaque monkeys

Local Connections of Layer 5 GABAergic Interneurons to Corticospinal Neurons

Axonal connections between S1 barrel, M1, and S2 cortex in the newborn mouse

Intrinsic Electrophysiology of Mouse Corticospinal Neurons: a Class-Specific Triad of Spike-Related Properties

eGFP Expression under UCHL1 Promoter Genetically Labels Corticospinal Motor Neurons and a Subpopulation of Degeneration-Resistant Spinal Motor Neurons in an ALS Mouse Model

Activity-Dependent Plasticity Improves M1 Motor Representation and Corticospinal Tract Connectivity

Large-scale M1 microcircuit model with plastic input connections from biological PMd neurons used for prosthetic arm control

Distinct Balance of Excitation and Inhibition in an Interareal Feedforward and Feedback Circuit of Mouse Visual Cortex

Spike-timing dependent plasticity in primate corticospinal connections induced during free behavior

Reciprocal Interareal Connections to Corticospinal Neurons in Mouse M1 and S2

Similar Documents

The activity of M1 corticospinal neurons during tool use by macaque monkeys

Local Connections of Layer 5 GABAergic Interneurons to Corticospinal Neurons

Axonal connections between S1 barrel, M1, and S2 cortex in the newborn mouse

Intrinsic Electrophysiology of Mouse Corticospinal Neurons: a Class-Specific Triad of Spike-Related Properties

eGFP Expression under UCHL1 Promoter Genetically Labels Corticospinal Motor Neurons and a Subpopulation of Degeneration-Resistant Spinal Motor Neurons in an ALS Mouse Model

Activity-Dependent Plasticity Improves M1 Motor Representation and Corticospinal Tract Connectivity

Large-scale M1 microcircuit model with plastic input connections from biological PMd neurons used for prosthetic arm control

Distinct Balance of Excitation and Inhibition in an Interareal Feedforward and Feedback Circuit of Mouse Visual Cortex

Spike-timing dependent plasticity in primate corticospinal connections induced during free behavior

Reciprocal Interareal Connections to Corticospinal Neurons in Mouse M1 and S2