NDLI: The role of dasatinib in the management of chronic myeloid leukemia

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Year: 2016, Volume: 10

Year: 2015, Volume: 10

Year: 2015, Volume: 9

Year: 2015, Volume: 9, Issue: Unspecified

Hidden costs of antiretroviral treatment: the public health efficiency of drug packaging

A prospective treatment for sepsis

Positive effects on hematological and biochemical imbalances in patients with metastatic breast cancer stage IV, of BP-C1, a new anticancer substance

Ultrasound contrast agent loaded with nitric oxide as a theranostic microdevice

Management of severe sepsis: advances, challenges, and current status

Paclitaxel attenuates renal interstitial fibroblast activation and interstitial fibrosis by inhibiting STAT3 signaling

Urinary kallidinogenase for the treatment of cerebral arterial stenosis

Bardoxolone methyl induces apoptosis and autophagy and inhibits epithelial-to-mesenchymal transition and stemness in esophageal squamous cancer cells

Involvement of NF-ΚB and HSP70 signaling pathways in the apoptosis of MDA-MB-231 cells induced by a prenylated xanthone compound, α-mangostin, from Cratoxylum arborescens [Corrigendum]

Tazarotene as alternative topical treatment for onychomycosis

Bu-Shen-Ning-Xin Decoction ameliorated the osteoporotic phenotype of ovariectomized mice without affecting the serum estrogen concentration or uterus

Estimation of the binding modes with important human cytochrome P450 enzymes, drug interaction potential, pharmacokinetics, and hepatotoxicity of ginger components using molecular docking, computational, and pharmacokinetic modeling studies

MicroRNA-133b targets glutathione S-transferase π expression to increase ovarian cancer cell sensitivity to chemotherapy drugs

Design and in vivo evaluation of oxycodone once-a-day controlled-release tablets

Reverse phase protein arrays in signaling pathways: a data integration perspective

A single-arm Phase II validation study of preventing oxaliplatin-induced hypersensitivity reactions by dexamethasone: the AVOID trial

Screening strategies to identify HSP70 modulators to treat Alzheimer’s disease

Lost expression of ADAMTS5 protein associates with progression and poor prognosis of hepatocellular carcinoma

Plumbagin induces cell cycle arrest and autophagy and suppresses epithelial to mesenchymal transition involving PI3K/Akt/mTOR-mediated pathway in human pancreatic cancer cells

Synergistic antitumor effect of adenovirus armed with Drosophila melanogaster deoxyribonucleoside kinase and nucleoside analogs for human breast carcinoma in vitro and in vivo

Preparation and characterization of genipin-cross-linked silk fibroin/chitosan sustained-release microspheres

Differential benefit risk assessment of DOACs in the treatment of venous thromboembolism: focus on dabigatran

Pharmacokinetics, pharmacodynamics, and tolerability of LC350189, a novel xanthine oxidase inhibitor, in healthy subjects

Pharmacokinetics and bioavailability study of two ondansetron oral soluble film formulations in fasting healthy male Chinese volunteers

In silico approach for the discovery of new PPARγ modulators among plant-derived polyphenols

Simvastatin prevents isoproterenol-induced cardiac hypertrophy through modulation of the JAK/STAT pathway

High-throughput virtual screening with e-pharmacophore and molecular simulations study in the designing of pancreatic lipase inhibitors

Stability of refrigerated miglustat after preparation in InOrpha® flavored suspending excipient for compounding of oral solutions and suspensions

Osteopontin promotes dendritic cell maturation and function in response to HBV antigens

Investigation of the bioequivalence of montelukast chewable tablets after a single oral administration using a validated LC-MS/MS method

Design and prediction of new anticoagulants as a selective Factor IXa inhibitor via three-dimensional quantitative structure-property relationships of amidinobenzothiophene derivatives

Modifying tetramethyl–nitrophenyl–imidazoline with amino acids: design, synthesis, and 3D-QSAR for improving inflammatory pain therapy

The association of CXCR4 expression with clinicopathological significance and potential drug target in prostate cancer: a meta-analysis and literature review

Cardioprotection against ischemia/reperfusion injury by QiShenYiQi Pill® via ameliorate of multiple mitochondrial dysfunctions

Association of systolic blood pressure drop with intravenous administration of itraconazole in children with hemato-oncologic disease

Alisertib, an Aurora kinase A inhibitor, induces apoptosis and autophagy but inhibits epithelial to mesenchymal transition in human epithelial ovarian cancer cells

Effect of lactoferrin protein on red blood cells and macrophages: mechanism of parasite–host interaction

Clinical development of galunisertib (LY2157299 monohydrate), a small molecule inhibitor of transforming growth factor-beta signaling pathway

Assessment of prescribing, dispensing, and patient use pattern of antihypertensive drugs for patients attending outpatient department of Hiwot Fana Specialized University Hospital, Harar, Eastern Ethiopia

Optimization of caseinate-coated simvastatin-zein nanoparticles: improved bioavailability and modified release characteristics

Paeonia lactiflora Pall. protects against ANIT-induced cholestasis by activating Nrf2 via PI3K/Akt signaling pathway

Combination therapy of ursodeoxycholic acid and budesonide for PBC–AIH overlap syndrome: a meta-analysis

Colon-targeted delivery of budesonide using dual pH- and time-dependent polymeric nanoparticles for colitis therapy

Alisertib induces cell cycle arrest and autophagy and suppresses epithelial-to-mesenchymal transition involving PI3K/Akt/mTOR and sirtuin 1-mediated signaling pathways in human pancreatic cancer cells

A bioinformatic and mechanistic study elicits the antifibrotic effect of ursolic acid through the attenuation of oxidative stress with the involvement of ERK, PI3K/Akt, and p38 MAPK signaling pathways in human hepatic stellate cells and rat liver

Colon-targeted delivery of piceatannol enhances anti-colitic effects of the natural product: potential molecular mechanisms for therapeutic enhancement

Enhanced antitumoral activity of doxorubicin against lung cancer cells using biodegradable poly(butylcyanoacrylate) nanoparticles

Oxidant/antioxidant status, paraoxonase activity, and lipid profile in plasma of ovariectomized rats under the influence of estrogen, estrogen combined with progesterone, and genistein

Investigation of cyclooxygenase and signaling pathways involved in human platelet aggregation mediated by synergistic interaction of various agonists

Antitumor effects of traditional Chinese medicine targeting the cellular apoptotic pathway

Plumbagin induces G2/M arrest, apoptosis, and autophagy via p38 MAPK- and PI3K/Akt/mTOR-mediated pathways in human tongue squamous cell carcinoma cells

Koenimbin, a natural dietary compound of Murraya koenigii (L) Spreng: inhibition of MCF7 breast cancer cells and targeting of derived MCF7 breast cancer stem cells (CD44+/CD24−/low): an in vitro study

Effect of renal impairment on the pharmacokinetics of levomilnacipran following a single oral dose of levomilnacipran extended-release capsule in humans

Identification of covalent active site inhibitors of dengue virus protease

Developments in managing severe chronic pain: role of oxycodone–naloxone extended release

Population pharmacokinetics of methylphenidate hydrochloride extended-release multiple-layer beads in pediatric subjects with attention deficit hyperactivity disorder

Comparison of the pharmacokinetics and tolerability of HCP1004 (a fixed-dose combination of naproxen and esomeprazole strontium) and VIMOVO® (a marketed fixed-dose combination of naproxen and esomeprazole magnesium) in healthy volunteers

Profile of atacicept and its potential in the treatment of systemic lupus erythematosus

Tumor-induced VEGF-C overexpression in retroperitoneal lymph nodes in VX2 carcinoma-bearing rabbits

Therapeutic effects of C-28 methyl ester of 2-cyano-3,12-dioxoolean-1,9-dien-28-oic acid (CDDO-Me; bardoxolone methyl) on radiation-induced lung inflammation and fibrosis in mice

Blood pyrrole-protein adducts as a diagnostic and prognostic index in pyrrolizidine alkaloid-hepatic sinusoidal obstruction syndrome

Influence of glucosamine on the bioactivity of insulin delivered subcutaneously and in an oral nanodelivery system

Bacteriophage-based therapy in cystic fibrosis-associated Pseudomonas aeruginosa infections: rationale and current status

Efficacy and safety of a vaginal medicinal product containing three strains of probiotic bacteria: a multicenter, randomized, double-blind, and placebo-controlled trial

Tongguan capsule ameliorates coronary artery stenosis in a 40-year-old woman

Gelatin nanoparticle-mediated intranasal delivery of substance P protects against 6-hydroxydopamine-induced apoptosis: an in vitro and in vivo study

Celecoxib coupled to dextran via a glutamic acid linker yields a polymeric prodrug suitable for colonic delivery

Dendrimer-coupled sonophoresis-mediated transdermal drug-delivery system for diclofenac

How we make cell therapy in Italy

Induction of apoptosis and autophagy via sirtuin1- and PI3K/Akt/mTOR-mediated pathways by plumbagin in human prostate cancer cells

Nanoethosomal transdermal delivery of vardenafil for treatment of erectile dysfunction: optimization, characterization, and in vivo evaluation

Profile of paritaprevir/ritonavir/ombitasvir plus dasabuvir in the treatment of chronic hepatitis C virus genotype 1 infection

A quest to increase safety of anesthetics by advancements in anesthesia monitoring: scientometric analysis

Effect of curcumin on aging retinal pigment epithelial cells

The rapid effects of budesonide plus formoterol in patients with obstructive airway diseases

Adenoviral delivery of truncated MMP-8 fused with the hepatocyte growth factor mutant 1K1 ameliorates liver cirrhosis and promotes hepatocyte proliferation

The brain signature of paracetamol in healthy volunteers: a double-blind randomized trial

Clinically significant drug–drug interactions involving opioid analgesics used for pain treatment in patients with cancer: a systematic review

Pharmacokinetic and nephroprotective benefits of using Schisandra chinensis extracts in a cyclosporine A-based immune-suppressive regime

Effects of combined dietary supplementation with fenofibrate and Schisandrae Fructus pulp on lipid and glucose levels and liver function in normal and hypercholesterolemic mice

Hyaluronic acid abrogates ethanol-dependent inhibition of collagen biosynthesis in cultured human fibroblasts

Translational challenges of animal models in Chagas disease drug development: a review

Clinical evaluation of the efficacy and safety of a medical device in various forms containing Triticum vulgare for the treatment of venous leg ulcers – a randomized pilot study

Single dose pharmacokinetics of the novel transdermal donepezil patch in healthy volunteers

Proteomic response to 5,6-dimethylxanthenone 4-acetic acid (DMXAA, vadimezan) in human non-small cell lung cancer A549 cells determined by the stable-isotope labeling by amino acids in cell culture (SILAC) approach

Mechanisms underlying the perifocal neuroprotective effect of the Nrf2–ARE signaling pathway after intracranial hemorrhage

A novel derivative of doxorubicin, AD198, inhibits canine transitional cell carcinoma and osteosarcoma cells in vitro

Reductive metabolism of oxymatrine is catalyzed by microsomal CYP3A4

The clinicopathological significance of CDH1 in gastric cancer: a meta-analysis and systematic review

Prospective study on nanoparticle albumin-bound paclitaxel in advanced breast cancer: clinical results and biological observations in taxane-pretreated patients

Rare sugar d-psicose prevents progression and development of diabetes in T2DM model Otsuka Long-Evans Tokushima Fatty rats

Complete genome-wide screening and subtractive genomic approach revealed new virulence factors, potential drug targets against bio-war pathogen Brucella melitensis 16M

Organic anion transporter 3- and organic anion transporting polypeptides 1B1- and 1B3-mediated transport of catalposide

Combination therapy of fenofibrate and ursodeoxycholic acid in patients with primary biliary cirrhosis who respond incompletely to UDCA monotherapy: a meta-analysis

Profile of deferasirox for the treatment of patients with non-transfusion-dependent thalassemia syndromes

A phase 1 randomized study evaluating the effect of omeprazole on the pharmacokinetics of a novel 5-hydroxytryptamine receptor 4 agonist, revexepride (SSP-002358), in healthy adults

Hydrogen sulfide-releasing naproxen suppresses colon cancer cell growth and inhibits NF-κB signaling

Disposition and metabolism of [14C]-levomilnacipran, a serotonin and norepinephrine reuptake inhibitor, in humans, monkeys, and rats

Innovation of natural essential oil-loaded Orabase for local treatment of oral candidiasis

Functional magnetic resonance imaging is a powerful approach to probing the mechanism of action of therapeutic drugs that act on the central nervous system

Development of acquired factor V inhibitor after treatment with ceftazidime: a case report and review of the literature

Enzalutamide for the treatment of metastatic castration-resistant prostate cancer

Utilization of cytogenetic biomarkers as a tool for assessment of radiation injury and evaluation of radiomodulatory effects of various medicinal plants – a review

Profile of evolocumab and its potential in the treatment of hyperlipidemia

Danusertib, a potent pan-Aurora kinase and ABL kinase inhibitor, induces cell cycle arrest and programmed cell death and inhibits epithelial to mesenchymal transition involving the PI3K/Akt/mTOR-mediated signaling pathway in human gastric cancer AGS and NCI-N78 cells

Brentuximab vedotin for relapsed or refractory Hodgkin’s lymphoma

The role of aflibercept in the management of diabetic macular edema

Profile of omalizumab in the treatment of chronic spontaneous urticaria

Albumin-bound paclitaxel in solid tumors: clinical development and future directions

Pain relief and improved physical function in knee osteoarthritis patients receiving ongoing hylan G-F 20, a high-molecular-weight hyaluronan, versus other treatment options: data from a large real-world longitudinal cohort in Canada

Liraglutide reduces lipogenetic signals in visceral adipose of db/db mice with AMPK activation and Akt suppression

The pan-inhibitor of Aurora kinases danusertib induces apoptosis and autophagy and suppresses epithelial-to-mesenchymal transition in human breast cancer cells

Characterization of renal biomarkers for use in clinical trials: effect of preanalytical processing and qualification using samples from subjects with diabetes

Visual detection of glial cell line-derived neurotrophic factor based on a molecular translator and isothermal strand-displacement polymerization reaction

Synthesis, structural characterization, and anticancer activity of a monobenzyltin compound against MCF-7 breast cancer cells

Design, development, drug-likeness, and molecular docking studies of novel piperidin-4-imine derivatives as antitubercular agents

Incidence and risk of hypertension with bevacizumab in non-small-cell lung cancer patients: a meta-analysis of randomized controlled trials

Emerging options for the treatment of type 2 diabetes in Chinese patients: focus on arterial function and alogliptin

Wnt blockers inhibit the proliferation of lung cancer stem cells

Liriodenine, an aporphine alkaloid from Enicosanthellum pulchrum, inhibits proliferation of human ovarian cancer cells through induction of apoptosis via the mitochondrial signaling pathway and blocking cell cycle progression

Novel targeting of PEGylated liposomes for codelivery of TGF-β1 siRNA and four antitubercular drugs to human macrophages for the treatment of mycobacterial infection: a quantitative proteomic study

Nutrigenomic effects of edible bird’s nest on insulin signaling in ovariectomized rats

Structure–activity exploration of a small-molecule Lipid II inhibitor

High-throughput sequencing of 16S rDNA amplicons characterizes bacterial composition in bronchoalveolar lavage fluid in patients with ventilator-associated pneumonia

Effect of database profile variation on drug safety assessment: an analysis of spontaneous adverse event reports of Japanese cases

Comments on a systematic review and meta-analysis of steroids for epidural injections in spinal stenosis

Spotlight on tavaborole for the treatment of onychomycosis

Aterofisiol® in carotid plaque evolution

Evaluation of the efficacy and safety of three dosing regimens of agalsidase alfa enzyme replacement therapy in adults with Fabry disease

Combination of erlotinib and a PARP inhibitor inhibits growth of A2780 tumor xenografts due to increased autophagy

Design of a new therapy for patients with chronic kidney disease: use of microarrays for selective hemoadsorption of uremic wastes and toxins to improve homeostasis

Lipopolysaccharide-induced caveolin-1 phosphorylation-dependent increase in transcellular permeability precedes the increase in paracellular permeability

Development of telmisartan in the therapy of spinal cord injury: pre-clinical study in rats

The mechanism of CCN1-enhanced retinal neovascularization in oxygen-induced retinopathy through PI3K/Akt–VEGF signaling pathway

Comment on a meta-analysis comparing hepatic resection or transarterial chemoembolization as initial treatment for hepatocellular carcinoma

Cryo-ablation improves anti-tumor immunity through recovering tumor educated dendritic cells in tumor-draining lymph nodes

Pro-apoptotic and pro-autophagic effects of the Aurora kinase A inhibitor alisertib (MLN8237) on human osteosarcoma U-2 OS and MG-63 cells through the activation of mitochondria-mediated pathway and inhibition of p38 MAPK/PI3K/Akt/mTOR signaling pathway

Paracellular permeation-enhancing effect of AT1002 C-terminal amidation in nasal delivery

Combined treatment with olmesartan medoxomil and amlodipine besylate attenuates atherosclerotic lesion progression in a model of advanced atherosclerosis

The investigational Aurora kinase A inhibitor alisertib (MLN8237) induces cell cycle G2/M arrest, apoptosis, and autophagy via p38 MAPK and Akt/mTOR signaling pathways in human breast cancer cells

Liraglutide and obesity: a review of the data so far

Development of biosimilars in an era of oncologic drug shortages

Anesthetic drug midazolam inhibits cardiac human ether-à-go-go-related gene channels: mode of action

RGD-modified liposomes enhance efficiency of aclacinomycin A delivery: evaluation of their effect in lung cancer

Randomized, open-label, blinded-endpoint, crossover, single-dose study to compare the pharmacodynamics of torasemide-PR 10 mg, torasemide-IR 10 mg, and furosemide-IR 40 mg, in patients with chronic heart failure

Distinct prognostic values and potential drug targets of ALDH1 isoenzymes in non-small-cell lung cancer

Role of sodium tungstate as a potential antiplatelet agent

Study of bone-like hydroxyapatite/polyamino acid composite materials for their biological properties and effects on the reconstruction of long bone defects

DNAzyme-based probe for circulating microRNA detection in peripheral blood

CTGF siRNA ameliorates tubular cell apoptosis and tubulointerstitial fibrosis in obstructed mouse kidneys in a Sirt1-independent manner

Development and in vitro characterization of drug delivery system of rifapentine for osteoarticular tuberculosis

Modeling, molecular dynamics, and docking assessment of transcription factor rho: a potential drug target in Brucella melitensis 16M

Promoting endothelial function by S-nitrosoglutathione through the HIF-1α/VEGF pathway stimulates neurorepair and functional recovery following experimental stroke in rats

Update on the management of severe hypertriglyceridemia – focus on free fatty acid forms of omega-3

Em08red, a dual functional antiproliferative emodin analogue, is a downregulator of ErbB2 expression and inducer of intracellular oxidative stress

Crizotinib as a personalized alternative for targeted anaplastic lymphoma kinase rearrangement in previously treated patients with non-small-cell lung cancer

Relaxin inhibits cardiac fibrosis and endothelial–mesenchymal transition via the Notch pathway

Sample sizes in dosage investigational clinical trials: a systematic evaluation

Nanoparticle formulation by Büchi B-90 Nano Spray Dryer for oral mucoadhesion

Development of intramammary delivery systems containing lasalocid for the treatment of bovine mastitis: impact of solubility improvement on safety, efficacy, and milk distribution in dairy cattle

Construction of interference vector targeting Ep-CAM gene and its effects on colorectal cancer cell proliferation

Critical appraisal of Timothy grass pollen extract GRAZAX® in the management of allergic rhinitis

The role of taxanes in triple-negative breast cancer: literature review [Corrigendum]

Custom fractional factorial designs to develop atorvastatin self-nanoemulsifying and nanosuspension delivery systems – enhancement of oral bioavailability

Role of short-acting nitroglycerin in the management of ischemic heart disease

PACE4 regulates apoptosis in human prostate cancer cells via endoplasmic reticulum stress and mitochondrial signaling pathways

Protective effects of alginate–chitosan microspheres loaded with alkaloids from Coptis chinensis Franch. and Evodia rutaecarpa (Juss.) Benth. (Zuojin Pill) against ethanol-induced acute gastric mucosal injury in rats

Clinicopathological significance of CXCR4 in non-small cell lung cancer

Clinical pharmacokinetics of AZD3199, an inhaled ultra-long-acting β2-adrenoreceptor agonist (uLABA)

Advantageous effects of immunosuppression with tacrolimus in comparison with cyclosporine A regarding renal function in patients after heart transplantation

Arsenic sulfide combined with JQ1, chemotherapy agents, or celecoxib inhibit gastric and colon cancer cell growth

Decreased expression of the APOA1–APOC3–APOA4 gene cluster is associated with risk of Alzheimer’s disease

Turoctocog alfa: an evidence-based review of its potential in the treatment of hemophilia A

Noncoding RNAs as potential biomarkers to predict the outcome in pancreatic cancer

PTEN insufficiency modulates ER+ breast cancer cell cycle progression and increases cell growth in vitro and in vivo

A pharmacokinetic and pharmacodynamic drug interaction between rosuvastatin and valsartan in healthy subjects

Pooled post hoc analysis of population pharmacokinetics of oxycodone and acetaminophen following a single oral dose of biphasic immediate-release/extended-release oxycodone/acetaminophen tablets

Human colon carcinogenesis is associated with increased interleukin-17-driven inflammatory responses

Treatment with a herbal formula B401 enhances neuroprotection and angiogenesis in the R6/2 mouse model of Huntington’s disease

Attenuation of myocardial fibrosis with curcumin is mediated by modulating expression of angiotensin II AT1/AT2 receptors and ACE2 in rats

Effect of aliskiren on cardiovascular outcomes in patients with prehypertension: a meta-analysis of randomized controlled trials

Inhibition of cyclooxygenase-2 prevents intra-abdominal adhesions by decreasing activity of peritoneal fibroblasts

Exposure–outcome analysis in depressed patients treated with paroxetine using population pharmacokinetics

Anticancer activity of streptochlorin, a novel antineoplastic agent, in cholangiocarcinoma

Dose proportionality and pharmacokinetics of carvedilol sustained-release formulation: a single dose-ascending 10-sequence incomplete block study

Comparative efficacy, tolerability, and survival outcomes of various radiopharmaceuticals in castration-resistant prostate cancer with bone metastasis: a meta-analysis of randomized controlled trials

Body protective compound-157 enhances alkali-burn wound healing in vivo and promotes proliferation, migration, and angiogenesis in vitro

Neuroprotective therapies for glaucoma

Protective effect of Huang Gan formula in 5/6 nephrectomized rats by depressing the Wnt/β-catenin signaling pathway

A computational and functional study elicits the ameliorating effect of the Chinese herbal formula Huo Luo Xiao Ling Dan on experimental ischemia-induced myocardial injury in rats via inhibition of apoptosis

Repurposing paclitaxel for the treatment of fibrosis: indication discovery for existing drugs

Selective use of vandetanib in the treatment of thyroid cancer

Efficacy and tolerability of oral oxycodone and oxycodone/naloxone combination in opioid-naïve cancer patients: a propensity analysis

Itraconazole solid dispersion prepared by a supercritical fluid technique: preparation, in vitro characterization, and bioavailability in beagle dogs

Design, synthesis, and antitumor evaluation of histone deacetylase inhibitors with l-phenylglycine scaffold

Ghrelin reduces liver impairment in a model of concanavalin A-induced acute hepatitis in mice

Borreliacidal activity of Borrelia metal transporter A (BmtA) binding small molecules by manganese transport inhibition

Intravitreal anti-VEGF injections for treating wet age-related macular degeneration: a systematic review and meta-analysis

Transarterial chemoembolization versus hepatic resection in hepatocellular carcinoma treatment: a meta-analysis

Novel levocetirizine HCl tablets with enhanced palatability: synergistic effect of combining taste modifiers and effervescence technique

Treatment of Staphylococcus aureus-induced chronic osteomyelitis with bone-like hydroxyapatite/poly amino acid loaded with rifapentine microspheres

Pharmacokinetic interaction between udenafil and dapoxetine: a randomized, open-labeled crossover study in healthy male volunteers

Apatinib for molecular targeted therapy in tumor

The study on the preparation and characterization of gene-loaded immunomagnetic albumin nanospheres and their anti-cell proliferative effect combined with magnetic fluid hyperthermia on GLC-82 cells

Understanding the cross-resistance of oseltamivir to H1N1 and H5N1 influenza A neuraminidase mutations using multidimensional computational analyses

Development of megestrol acetate solid dispersion nanoparticles for enhanced oral delivery by using a supercritical antisolvent process

Design of a gelatin microparticle-containing self-microemulsifying formulation for enhanced oral bioavailability of dutasteride

The role of Gliadel wafers in the treatment of newly diagnosed GBM: a meta-analysis

High glucose inhibits ClC-2 chloride channels and attenuates cell migration of rat keratinocytes

Fixed-combination treatments for intraocular hypertension in Chinese patients – focus on bimatoprost-timolol

Ferrous sulfate, but not iron polymaltose complex, aggravates local and systemic inflammation and oxidative stress in dextran sodium sulfate-induced colitis in rats

Navigating the chemical space of dipeptidyl peptidase-4 inhibitors

Apparent histological changes of adipocytes after treatment with CL 316,243, a β-3-adrenergic receptor agonist

Systematic review and meta-analysis: bezafibrate in patients with primary biliary cirrhosis

Apparent Km of mitochondria for oxygen computed from Vmax measured in permeabilized muscle fibers is lower in water enriched in oxygen by electrolysis than injection

Ginkgo biloba extract mitigates liver fibrosis and apoptosis by regulating p38 MAPK, NF-κB/IκBα, and Bcl-2/Bax signaling

Neuroprotective and antioxidant effects of ghrelin in an experimental glaucoma model

Comparative efficacy, acceptability, and tolerability of lisdexamfetamine in child and adolescent ADHD: a meta-analysis of randomized, controlled trials

1-1-12 one-step wash-in scheme for desflurane low flow anesthesia: performance without nitrous oxide

Paeoniflorin inhibits human glioma cells via STAT3 degradation by the ubiquitin–proteasome pathway

Dose-dependent effects of atorvastatin on myocardial infarction

Design and evaluation of effervescent floating tablets based on hydroxyethyl cellulose and sodium alginate using pentoxifylline as a model drug

Insight into the mechanism of polyphenols on the activity of HMGR by molecular docking

Dacomitinib in lung cancer: a “lost generation” EGFR tyrosine-kinase inhibitor from a bygone era?

The antiplasmodial and spleen protective role of crude Indigofera oblongifolia leaf extract traditionally used in the treatment of malaria in Saudi Arabia

Prevalence of the CYP2D6*10 (C100T), *4 (G1846A), and *14 (G1758A) alleles among Iranians of different ethnicities

Skin regeneration in deep second-degree scald injuries either by infusion pumping or topical application of recombinant human erythropoietin gel

Therapeutic designed poly (lactic-co-glycolic acid) cylindrical oseltamivir phosphate-loaded implants impede tumor neovascularization, growth and metastasis in mouse model of human pancreatic carcinoma

Efficacy and safety of ifosfamide-based chemotherapy for osteosarcoma: a meta-analysis

Depot injectable biodegradable nanoparticles loaded with recombinant human bone morphogenetic protein-2: preparation, characterization, and in vivo evaluation

Characterization of preclinical in vitro and in vivo pharmacokinetics properties for KBP-7018, a new tyrosine kinase inhibitor candidate for treatment of idiopathic pulmonary fibrosis

Clinicopathological significance and potential drug targeting of CDH1 in lung cancer: a meta-analysis and literature review

Glucose abnormalities in Asian patients with chronic hepatitis C

A fixed-dose combination tablet of gemigliptin and metformin sustained release has comparable pharmacodynamic, pharmacokinetic, and tolerability profiles to separate tablets in healthy subjects

Met tyrosine kinase inhibitor, PF-2341066, suppresses growth and invasion of nasopharyngeal carcinoma

Evaluation of the protective effects of curcuminoid (curcumin and bisdemethoxycurcumin)-loaded liposomes against bone turnover in a cell-based model of osteoarthritis

Paget’s disease of bone: an osteoimmunological disorder?

Protective effect of galangin in Concanavalin A-induced hepatitis in mice

Antitumor activity of SA12, a novel peptide, on SKBr-3 breast cancer cells via the mitochondrial apoptosis pathway

Design, synthesis, and antifungal activities of novel triazole derivatives containing the benzyl group

Acquired latent tuberculosis infection in psoriasis patients treated with etanercept in the People’s Republic of China

Exposure–response model for sibutramine and placebo: suggestion for application to long-term weight-control drug development

Altered γ-aminobutyric acid neurotransmission in major depressive disorder: a critical review of the supporting evidence and the influence of serotonergic antidepressants

Navigating into the binding pockets of the HER family protein kinases: discovery of novel EGFR inhibitor as antitumor agent

Impact of potential inappropriate NSAIDs use in chronic pain

Green tea extract as a treatment for patients with wild-type transthyretin amyloidosis: an observational study

n-Butanol extract from Folium isatidis inhibits lipopolysaccharide-induced inflammatory cytokine production in macrophages and protects mice against lipopolysaccharide-induced endotoxic shock

Development of PPAR-agonist GW0742 as antidiabetic drug: study in animals

Companion diagnostics and molecular imaging-enhanced approaches for oncology clinical trials

Xiaokeping mixture inhibits diabetic nephropathy in streptozotocin-induced rats through blocking TGF-β1/Smad7 signaling

Effect of caffeic acid phenethyl ester on bone formation in the expanded inter-premaxillary suture

Emerging therapies for patients with symptoms of opioid-induced bowel dysfunction

Single and multiple dose pharmacokinetics and tolerability of HX-1171, a novel antioxidant, in healthy volunteers

Immunosuppressive effects of the standardized extract of Phyllanthus amarus on cellular immune responses in Wistar-Kyoto rats

Solifenacin/tamsulosin fixed-dose combination therapy to treat lower urinary tract symptoms in patients with benign prostatic hyperplasia

The clinicopathological significance and drug target potential of FHIT in breast cancer, a meta-analysis and literature review

The pitfall of the transient, inconsistent anticancer capacity of antiestrogens and the mechanism of apparent antiestrogen resistance

6-Gingerol alleviates exaggerated vasoconstriction in diabetic rat aorta through direct vasodilation and nitric oxide generation

A novel small-molecule inhibitor of HIV-1 entry

Improvement of oral bioavailability of lovastatin by using nanostructured lipid carriers

Clinical utility of eslicarbazepine: current evidence

DNA stabilization by the upregulation of estrogen signaling in BRCA gene mutation carriers

Chamaejasmin B exerts anti-MDR effect in vitro and in vivo via initiating mitochondria-dependant intrinsic apoptosis pathway

Effects of histamine and its antagonists on murine T-cells and bone marrow-derived dendritic cells

Idiopathic pulmonary fibrosis: current treatment options and critical appraisal of nintedanib

Applications of calixarenes in cancer chemotherapy: facts and perspectives

Edible bird’s nest attenuates procoagulation effects of high-fat diet in rats

A pharmacokinetic comparison of two voriconazole formulations and the effect of CYP2C19 polymorphism on their pharmacokinetic profiles

HDACiDB: a database for histone deacetylase inhibitors

Empagliflozin in the treatment of type 2 diabetes: evidence to date

Impact of streptozotocin on altering normal glucose homeostasis during insulin testing in diabetic rats compared to normoglycemic rats

Phytocompounds and modulatory effects of Anacardium microcarpum (cajui) on antibiotic drugs used in clinical infections

Histone demethylase LSD1-mediated repression of GATA-2 is critical for erythroid differentiation

Ultrasound effects on brain-targeting mannosylated liposomes: in vitro and blood–brain barrier transport investigations

Lefty-1 alleviates TGF-β1-induced fibroblast–myofibroblast transdifferentiation in NRK-49F cells

Development of lovastatin-loaded poly(lactic acid) microspheres for sustained oral delivery: in vitro and ex vivo evaluation

The effect of curcumin and its nanoformulation on adjuvant-induced arthritis in rats

Radiotherapy potentiation with weekly cisplatin compared to standard every 3 weeks cisplatin chemotherapy for locoregionally advanced head and neck squamous cell carcinoma

Pharmacokinetics, pharmacodynamics, and safety of lesinurad, a selective uric acid reabsorption inhibitor, in healthy adult males

Evaluation of trends of drug-prescribing patterns based on WHO prescribing indicators at outpatient departments of four hospitals in southern Ethiopia

Improved oral absorption of cilostazol via sulfonate salt formation with mesylate and besylate

Novel nanoliposomal delivery system for polydatin: preparation, characterization, and in vivo evaluation

Recent progress in fungus-derived bioactive agents for targeting of signaling machinery in cancer cells

Stepwise design, synthesis, and in vitro antifungal screening of (Z)-substituted-propenoic acid derivatives with potent broad-spectrum antifungal activity

Profile of ceftolozane/tazobactam and its potential in the treatment of complicated intra-abdominal infections

The efficacy and safety of pemetrexed-based doublet therapy compared to pemetrexed alone for the second-line treatment of advanced non-small-cell lung cancer: an updated meta-analysis

Aclidinium bromide/formoterol fixed-dose combination therapy for COPD: the evidence to date

D-cycloserine augmentation in behavioral therapy for obsessive-compulsive disorder: a meta-analysis

Enhanced anti-inflammatory potential of cinnamate-zinc layered hydroxide in lipopolysaccharide-stimulated RAW 264.7 macrophages

The role of dasatinib in the management of chronic myeloid leukemia

A study on the hemocompatibility of dendronized chitosan derivatives in red blood cells

3-Coumaranone derivatives as inhibitors of monoamine oxidase

Pancreatic cancer: optimizing treatment options, new, and emerging targeted therapies

Preparation, characterization, and in vivo study of rhein-loaded poly(lactic-co-glycolic acid) nanoparticles for oral delivery

Tacrolimus in preventing transplant rejection in Chinese patients – optimizing use

Treatment with metformin and a dipeptidyl peptidase-4 inhibitor elevates apelin levels in patients with type 2 diabetes mellitus

Bioequivalence evaluation of two amlodipine salts, besylate and orotate, each in a fixed-dose combination with olmesartan in healthy subjects

Epidural injections with or without steroids in managing chronic low back pain secondary to lumbar spinal stenosis: a meta-analysis of 13 randomized controlled trials

Assessment of hydroxychloroquine maculopathy after cessation of treatment: an optical coherence tomography and multifocal electroretinography study

Alpinetin inhibits lung cancer progression and elevates sensitization drug-resistant lung cancer cells to cis-diammined dichloridoplatium

Clinicopathological significance of matrix metalloproteinase-7 protein expression in esophageal cancer: a meta-analysis

Efficiency and safety of subconjunctival injection of anti-VEGF agent – bevacizumab – in treating dry eye

The mazEF toxin–antitoxin system as an attractive target in clinical isolates of Enterococcus faecium and Enterococcus faecalis

A meta-analysis for CXCR4 as a prognostic marker and potential drug target in non-small cell lung cancer

Enzymatic vitreolysis with recombinant tissue plasminogen activator for vitreomacular traction

Lack of the effect of lobeglitazone, a peroxisome proliferator-activated receptor-γ agonist, on the pharmacokinetics and pharmacodynamics of warfarin

A phase I/II study of biweekly capecitabine and irinotecan plus bevacizumab as second-line chemotherapy in patients with metastatic colorectal cancer

Soluplus®/TPGS-based solid dispersions prepared by hot-melt extrusion equipped with twin-screw systems for enhancing oral bioavailability of valsartan

Rationale and clinical utility of the darunavir–cobicistat combination in the treatment of HIV/AIDS

A meta-analysis for C-X-C chemokine receptor type 4 as a prognostic marker and potential drug target in hepatocellular carcinoma

Synthesis, antimicrobial and in vitro antitumor activities of a series of 1,2,3-thiadiazole and 1,2,3-selenadiazole derivatives

Brivaracetam: review of its pharmacology and potential use as adjunctive therapy in patients with partial onset seizures [Corrigendum]

Effects of strontium ranelate on bone formation in the mid-palatal suture after rapid maxillary expansion

Fluorescence detection of tramadol in healthy Chinese volunteers by high-performance liquid chromatography and bioequivalence assessment

Soy polysaccharide as a novel superdisintegrant in sildenafil citrate sublingual tablets: preparation, characterization, and in vivo evaluation

2-acetylphenol analogs as potent reversible monoamine oxidase inhibitors

Use of letrozole and clomiphene citrate combined with gonadotropins in clomiphene-resistant infertile women with polycystic ovary syndrome: a prospective study

Anthocyanins inhibit high-glucose-induced cholesterol accumulation and inflammation by activating LXRα pathway in HK-2 cells

Clinicopathological significance and potential drug target of CDH1 in breast cancer: a meta-analysis and literature review

Efficacy and safety of different doses of a slow-release corticosteroid implant for macular edema: meta-analysis of randomized controlled trials

Impact of enzyme replacement therapy and hematopoietic stem cell transplantation in patients with Morquio A syndrome

The effects of amlodipine and platelet rich plasma on bone healing in rats

A novel glycyrrhetinic acid-modified oxaliplatin liposome for liver-targeting and in vitro/vivo evaluation

Scientometrics of drug discovery efforts: pain-related molecular targets

Autophagy facilitates lung adenocarcinoma resistance to cisplatin treatment by activation of AMPK/mTOR signaling pathway

Effect of vitamin C on inflammation and metabolic markers in hypertensive and/or diabetic obese adults: a randomized controlled trial

Efficacy and safety of ramosetron versus ondansetron for postoperative nausea and vomiting after general anesthesia: a meta-analysis of randomized clinical trials

Escherichia coli Nissle 1917 bacterial ghosts retain crucial surface properties and express chlamydial antigen: an imaging study of a delivery system for the ocular surface

A novel misoprostol delivery system for induction of labor: clinical utility and patient considerations

HMG-CoA reductase inhibitory activity and phytocomponent investigation of Basella alba leaf extract as a treatment for hypercholesterolemia

Vipegitide: a folded peptidomimetic partial antagonist of α2β1 integrin with antiplatelet aggregation activity

Role of chymase in the local renin-angiotensin system in keloids: inhibition of chymase may be an effective therapeutic approach to treat keloids

4-Hydroxyisoleucine ameliorates an insulin resistant-like state in 3T3-L1 adipocytes by regulating TACE/TIMP3 expression

The first clinical experience on efficacy of topical flutamide on melasma compared with topical hydroquinone: a randomized clinical trial

Inhibition of mitotic Aurora kinase A by alisertib induces apoptosis and autophagy of human gastric cancer AGS and NCI-N78 cells

Sphingosine kinase 1 as an anticancer therapeutic target

Transgenic animal models for study of the pathogenesis of Huntington’s disease and therapy

Upregulation of PD-L1 and APE1 is associated with tumorigenesis and poor prognosis of gastric cancer

Different effects of statins on induction of diabetes mellitus: an experimental study

Effect of a topical copper indomethacin gel on inflammatory parameters in a rat model of osteoarthritis

Structural dynamics and inhibitor searching for Wnt-4 protein using comparative computational studies

Roles of Ca2+/calmodulin-dependent protein kinase II in subcellular expression of striatal N-Methyl-D-aspartate receptors in l-3, 4-dihydroxyphenylalanine-induced dyskinetic rats

Apolipoprotein M regulates the orphan nuclear receptor LRH-1 gene expression through binding to its promoter region in HepG2 cells

Effects of chalcone derivatives on players of the immune system

Characterization of cubosomes as a targeted and sustained transdermal delivery system for capsaicin

Maraviroc: a review of its use in HIV infection and beyond

Preparation and clinical evaluation of nano-transferosomes for treatment of erectile dysfunction

Development of a test for recording both visual and auditory reaction times, potentially useful for future studies in patients on opioids therapy

Effect of Clausena excavata Burm. f. (Rutaceae) leaf extract on wound healing and antioxidant activity in rats

Effect and mechanism of fluoxetine on electrophysiology in vivo in a rat model of postmyocardial infarction depression

Oleanolic acid induces mitochondrial-dependent apoptosis and G0/G1 phase arrest in gallbladder cancer cells

Anticancer activity of Nigella sativa (black seed) and its relationship with the thermal processing and quinone composition of the seed

Profile of atacicept and its potential in the treatment of systemic lupus erythematosus [Corrigendum]

Comparison of reendothelialization and neointimal formation with stents coated with antibodies against endoglin and CD34 in a porcine model

Myofibrotic malformation vessels: unique angiodysplasia toward the progression of hemorrhoidal disease

Changing the face of hepatitis C management – the design and development of sofosbuvir

Downregulation of miR203 induces overexpression of PIK3CA and predicts poor prognosis of gastric cancer patients

Efficacy of thrombomodulin for acute exacerbation of idiopathic pulmonary fibrosis and nonspecific interstitial pneumonia: a nonrandomized prospective study

Cissus quadrangularis inhibits IL-1β induced inflammatory responses on chondrocytes and alleviates bone deterioration in osteotomized rats via p38 MAPK signaling

Quinoline-based clioquinol and nitroxoline exhibit anticancer activity inducing FoxM1 inhibition in cholangiocarcinoma cells

Electrochemotherapy in combination with chemoradiotherapy in the treatment of oral carcinomas in advanced stages of disease: efficacy, safety, and clinical outcomes in a small number of selected cases

Gamma scintigraphic study of the hydrodynamically balanced matrix tablets of Metformin HCl in rabbits

In vivo determination of the diclofenac skin reservoir: comparison between passive, occlusive, and iontophoretic application

Antibiotic-modifying activity of riachin, a non-cyanogenic cyanoglycoside extracted from Bauhinia pentandra

Profile of suvorexant in the management of insomnia

Advances in cancer pain from bone metastasis

Efficacy and safety of a conversion from the original tacrolimus and mycophenolate mofetil to the generics Tacpan® and Mowel® after liver transplantation

Brentuximab vedotin for treatment of relapsed or refractory malignant lymphoma: results of a systematic review and meta-analysis of prospective studies

Isolation and evaluation of anticancer efficacy of stigmasterol in a mouse model of DMBA-induced skin carcinoma

Pirfenidone-loaded liposomes for lung targeting: preparation and in vitro/in vivo evaluation

Pentoxifylline and electromagnetic field improved bone fracture healing in rats

Development and optimization of carvedilol orodispersible tablets: enhancement of pharmacokinetic parameters in rabbits

Protective effects of triptolide on retinal ganglion cells in a rat model of chronic glaucoma

The chemopreventive potential of Curcuma purpurascens rhizome in reducing azoxymethane-induced aberrant crypt foci in rats

Steroids as an adjunct for reducing the incidence of proliferative vitreoretinopathy after rhegmatogenous retinal detachment surgery: a systematic review and meta-analysis

Urine metabolomics in rats after administration of ketamine

Phase II trial of docetaxel combined with nedaplatin for patients with recurrent and metastatic nasopharyngeal carcinoma

Effects of vitamin C treatment on collar-induced intimal thickening

The effect of ethanol sclerotherapy of 5 minutes duration on cyst diameter and rat ovarian tissue in simple ovarian cysts

Phase III study of pasireotide long-acting release in patients with metastatic neuroendocrine tumors and carcinoid symptoms refractory to available somatostatin analogues

Modeling the longitudinal latent effect of pregabalin on self-reported changes in sleep disturbances in outpatients with generalized anxiety disorder managed in routine clinical practice

Human mesenchymal stem cells as delivery of osteoprotegerin gene: homing and therapeutic effect for osteosarcoma

Glu-Trp-ONa or its acylated analogue (R-Glu-Trp-ONa) administration enhances the wound healing in the model of chronic skin wounds in rabbits

Enhancement of absorption and bioavailability of echinacoside by verapamil or clove oil

Gallic acid attenuates dextran sulfate sodium-induced experimental colitis in BALB/c mice

CXCR4 in breast cancer: oncogenic role and therapeutic targeting

Aging-related rotenone-induced neurochemical and behavioral deficits: role of SIRT2 and redox imbalance, and neuroprotection by AK-7

Exploration of natural product ingredients as inhibitors of human HMG-CoA reductase through structure-based virtual screening

Targeting the hypoxia pathway to treat pancreatic cancer

Clinical and pharmacological properties of incobotulinumtoxinA and its use in neurological disorders

Evaluation of combined famotidine with quercetin for the treatment of peptic ulcer: in vivo animal study

Wound healing: a new perspective on glucosylated tetrahydrocurcumin

Recent advances in combinatorial biosynthesis for drug discovery

The efficacy and safety of panitumumab in the treatment of patients with metastatic colorectal cancer: a meta-analysis from five randomized controlled trials

Design, synthesis, and computational studies on dihydropyrimidine scaffolds as potential lipoxygenase inhibitors and cancer chemopreventive agents

Pharmacoinformatics approach for investigation of alternative potential hepatitis C virus nonstructural protein 5B inhibitors

Antiaging therapy: a prospective hypothesis

Relationship between UGT1A1*6/*28 polymorphisms and severe toxicities in Chinese patients with pancreatic or biliary tract cancer treated with irinotecan-containing regimens

Collagenase IV plays an important role in regulating hair cycle by inducing VEGF, IGF-1, and TGF-β expression

Progesterone regulates the proliferation of breast cancer cells – in vitro evidence

Small-molecule BH3 mimetic and pan-Bcl-2 inhibitor AT-101 enhances the antitumor efficacy of cisplatin through inhibition of APE1 repair and redox activity in non-small-cell lung cancer

Insulin administration: present strategies and future directions for a noninvasive (possibly more physiological) delivery

Clinicopathological significance and potential drug target of RUNX3 in non-small cell lung cancer: a meta-analysis

Itraconazole solid dispersion prepared by a supercritical fluid technique: preparation, in vitro characterization, and bioavailability in beagle dogs [Corrigendum]

Synthesis and biological evaluation of a novel class of curcumin analogs as anti-inflammatory agents for prevention and treatment of sepsis in mouse model

Development of oral dispersible tablets containing prednisolone nanoparticles for the management of pediatric asthma

A novel in situ gel base of deacetylase gellan gum for sustained ophthalmic drug delivery of ketotifen: in vitro and in vivo evaluation

The impact of lipocalin-type-prostaglandin-D-synthase as a predictor of kidney disease in patients with type 2 diabetes

Eliglustat tartrate for the treatment of adults with type 1 Gaucher disease

The IL-17A G-197A and IL-17F 7488T/C polymorphisms are associated with increased risk of cancer in Asians: a meta-analysis

A perspective on the benefit-risk assessment for new and emerging pharmaceuticals in Japan

A current review of folate receptor alpha as a potential tumor target in non-small-cell lung cancer

Mechanisms underlying probucol-induced hERG-channel deficiency

Impact of JAK2(V617F) mutation status on treatment response to anagrelide in essential thrombocythemia: an observational, hypothesis-generating study

The very-rapid and the ultra-rapid virologic response to two treatment options in patients with chronic hepatitis C: an interim report of a prospective randomized comparative effectiveness study

A thorough QT study to assess the effects of tbo-filgrastim on cardiac repolarization in healthy subjects

Effect of varying doses of tamoxifen on ovarian histopathology, serum VEGF, and endothelin 1 levels in ovarian hyperstimulation syndrome: an experimental study

Cromoglycate, not ketotifen, ameliorated the injured effect of warm ischemia/reperfusion in rat liver: role of mast cell degranulation, oxidative stress, proinflammatory cytokine, and inducible nitric oxide synthase

Discovery of 3-n-butyl-2,3-dihydro-1H-isoindol-1-one as a potential anti-ischemic stroke agent

Steroid for epidural injection in spinal stenosis: a systematic review and meta-analysis

Ceftobiprole for the treatment of pneumonia: a European perspective

Targeting brain cells with glutathione-modulated nanoliposomes: in vitro and in vivo study

Comparative efficacy of pitavastatin and simvastatin in patients with hypercholesterolemia: a meta-analysis of randomized controlled clinical trials

Bu-Shen-Ning-Xin decoction: inhibition of osteoclastogenesis by abrogation of the RANKL-induced NFATc1 and NF-κB signaling pathways via selective estrogen receptor α

Dabigatran etexilate retards the initiation and progression of atherosclerotic lesions and inhibits the expression of oncostatin M in apolipoprotein E-deficient mice

Immunostimulatory effects of the standardized extract of Tinospora crispa on innate immune responses in Wistar Kyoto rats

Improved corneal bioavailability of ofloxacin: biodegradable microsphere-loaded ion-activated in situ gel delivery system

High-throughput sequencing of 16S rDNA amplicons characterizes bacterial composition in cerebrospinal fluid samples from patients with purulent meningitis

Adjunctive therapies to reduce thrombotic events in patients with a history of myocardial infarction: role of vorapaxar

Effects of amoxicillin/clavulanic acid on the pharmacokinetics of valproic acid

Synthesis of an anthraquinone derivative (DHAQC) and its effect on induction of G2/M arrest and apoptosis in breast cancer MCF-7 cell line

Evaluation of glycine-bearing celecoxib derivatives as a colon-specific mutual prodrug acting on nuclear factor-κB, an anti-inflammatory target

Sodium hyaluronate eye drops treatment for superficial corneal abrasion caused by mechanical damage: a randomized clinical trial in the People’s Republic of China

The usefulness of ozone treatment in spinal pain

Canakinumab as rescue therapy in familial Mediterranean fever refractory to conventional treatment

Association between glycemic control and antidiabetic drugs in type 2 diabetes mellitus patients with cardiovascular complications

Improving dissolution and oral bioavailability of pranlukast hemihydrate by particle surface modification with surfactants and homogenization

Profile of conbercept in the treatment of neovascular age-related macular degeneration

Phase II study of reintroduction of oxaliplatin for advanced colorectal cancer in patients previously treated with oxaliplatin and irinotecan: RE-OPEN study

Synthetic biology for pharmaceutical drug discovery

A novel bispecific immunotoxin delivered by human bone marrow-derived mesenchymal stem cells to target blood vessels and vasculogenic mimicry of malignant gliomas

Nanoparticle albumin-bound paclitaxel (nab-paclitaxel) as second-line chemotherapy in HER2-negative, taxane-pretreated metastatic breast cancer patients: prospective evaluation of activity, safety, and quality of life

In vitro and in vivo anti-angiogenic activity of girinimbine isolated from Murraya koenigii

A proposal for an individualized pharmacogenetic-guided isoniazid dosage regimen for patients with tuberculosis

Critical appraisal of bevacizumab in the treatment of ovarian cancer

Nonalcoholic steatohepatitis: emerging targeted therapies to optimize treatment options

Selective oropharyngeal decontamination versus selective digestive decontamination in critically ill patients: a meta-analysis of randomized controlled trials

Synthesis and characterization of tumor-targeted copolymer nanocarrier modified by transferrin

Pharmacokinetics of mitragynine in man

Timosaponin B-II ameliorates diabetic nephropathy via TXNIP, mTOR, and NF-κB signaling pathways in alloxan-induced mice

Comparative fasting bioavailability of two clopidogrel formulations in healthy Mediterranean volunteers: an in vitro–in vivo correlation

Death receptor and mitochondria-mediated hepatocyte apoptosis underlies liver dysfunction in rats exposed to organic pollutants from drinking water

20(S)-ginsenoside Rg3 promotes senescence and apoptosis in gallbladder cancer cells via the p53 pathway

Bifunctional fused polypeptide inhibits the growth and metastasis of breast cancer

Glycemic control and antidiabetic drugs in type 2 diabetes mellitus patients with renal complications

Anti-Warburg effect of rosmarinic acid via miR-155 in gastric cancer cells

Efficacy and safety of a herbal mixture (Viron® tablets) in the treatment of patients with chronic hepatitis C virus infection: a prospective, randomized, open-label, proof-of-concept study

The application of click chemistry in the synthesis of agents with anticancer activity

The biological effects of tocotrienol on bone: a review on evidence from rodent models

Zinc supplementation induces apoptosis and enhances antitumor efficacy of docetaxel in non-small-cell lung cancer

Pharmacokinetic-pharmacodynamic analysis to evaluate the effect of moxifloxacin on QT interval prolongation in healthy Korean male subjects

Letter to the editor: naltrexone sustained-release/bupropion sustained-release for the management of obesity: review of the data to date

Phenolic indeno[1,2-b]indoles as ABCG2-selective potent and non-toxic inhibitors stimulating basal ATPase activity

Safety and pharmacokinetics of dicloxacillin in healthy Chinese volunteers following single and multiple oral doses

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The role of dasatinib in the management of chronic myeloid leukemia

Content Provider	PubMed Central
Author	Chen, Runzhe Chen, Baoan
Copyright Year	2015
Abstract	Dasatinib is a second-generation tyrosine kinase inhibitor (TKI) for chronic, blastic, or accelerated phase chronic myeloid leukemia (CML) patients who are resistant or intolerant to previous treatment. It potently inhibits BCR/ABL and SRC-family kinases (SRC, LCK, HCK, YES, FYN, FGR, BLK, LYN, FRK), as well as c-KIT, PDGFR-a and -b, and ephrin receptor kinase. Various clinical trials have provided evidence that it has more durable complete hematologic and cytogenetic responses, as well as more potency in imatinib-resistant or -intolerant CML, and it has also shown its advantages in newly diagnosed CML compared to imatinib. In this review, we mainly focus on the structure, mechanisms, pharmacokinetics, and pharmacogenetics of dasatinib. We also summarize clinical trials with dasatinib on CML and provide our recommendations for dasatinib in the treatment of CML.
Related Links	http://dx.doi.org/10.2147/dddt.s80207
Ending Page	779
Starting Page	773
File Format	PDF
ISSN	11778881
e-ISSN	11778881
Journal	Drug Design, Development and Therapy
Volume Number	9
Language	English
Publisher	Dove Medical Press
Publisher Date	2015-02-01
Access Restriction	Open
Rights Holder	Dove Medical Press
Subject Keyword	Pharmacology Drug Discovery Pharmaceutical Science Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Drug Discovery Pharmacology Pharmaceutical Science

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