NDLI: The trace amine-associated receptor 1 modulates methamphetamine's neurochemical and behavioral effects

Content Provider	PubMed Central
Author	Cotter, Rachel Pei, Yue Mus, Liudmila Harmeier, Anja Gainetdinov, Raul R. Hoener, Marius C. Canales, Juan J.
Copyright Year	2015
Abstract	The newly discovered trace amine-associated receptor 1 (TAAR1) has the ability to regulate both dopamine function and psychostimulant action. Here, we tested in rats the ability of RO5203648, a selective TAAR1 partial agonist, to modulate the physiological and behavioral effects of methamphetamine (METH). In experiment 1, RO5203468 dose- and time-dependently altered METH-induced locomotor activity, manifested as an early attenuation followed by a late potentiation of METH's stimulating effects. In experiment 2, rats received a 14-day treatment regimen during which RO5203648 was co-administered with METH. RO5203648 dose-dependently attenuated METH-stimulated hyperactivity, with the effects becoming more apparent as the treatments progressed. After chronic exposure and 3-day withdrawal, rats were tested for locomotor sensitization. RO5203648 administration during the sensitizing phase prevented the development of METH sensitization. However, RO5203648, at the high dose, cross-sensitized with METH. In experiment 3, RO5203648 dose-dependently blocked METH self-administration without affecting operant responding maintained by sucrose, and exhibited lack of reinforcing efficacy when tested as a METH's substitute. Neurochemical data showed that RO5203648 did not affect METH-mediated DA efflux and uptake inhibition in striatal synaptosomes. In vivo, however, RO5203648 was able to transiently inhibit METH-induced accumulation of extracellular DA levels in the nucleus accumbens. Taken together, these data highlight the significant potential of TAAR1 to modulate METH's neurochemical and behavioral effects.
Related Links	http://dx.doi.org/10.3389/fnins.2015.00039
Starting Page	39
File Format	PDF
ISSN	1662453X
e-ISSN	1662453X
Journal	Frontiers in Neuroscience
Volume Number	9
Language	English
Publisher	Frontiers Media S.A.
Publisher Date	2015-02-01
Access Restriction	Open
Rights Holder	Frontiers Media S.A.
Subject Keyword	Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Neuroscience

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

The trace amine-associated receptor 1 modulates methamphetamine's neurochemical and behavioral effects

Trace Amine Associated Receptor 1 Modulates Behavioral Effects of Ethanol

Trace Amine Associated Receptor 1 Modulates Behavioral Effects of Ethanol

The trace amine associated receptor 1 agonist RO5263397 attenuates the induction of cocaine behavioral sensitization in rats

Trace Amines and the Trace Amine-Associated Receptor 1: Pharmacology, Neurochemistry, and Clinical Implications

Trace Amines and the Trace Amine-Associated Receptor 1: Pharmacology, Neurochemistry, and Clinical Implications

Augmentation of methamphetamine-induced behaviors in transgenic mice lacking the trace amine-associated receptor 1

Trace Amine Associated Receptor 1 Signaling in Activated Lymphocytes

Effects of the Trace Amine Associated Receptor 1 Agonist RO5263397 on Abuse-Related Behavioral Indices of Methamphetamine in Rats

The trace amine-associated receptor 1 modulates methamphetamine's neurochemical and behavioral effects

Similar Documents

The trace amine-associated receptor 1 modulates methamphetamine's neurochemical and behavioral effects

Trace Amine Associated Receptor 1 Modulates Behavioral Effects of Ethanol

Trace Amine Associated Receptor 1 Modulates Behavioral Effects of Ethanol

The trace amine associated receptor 1 agonist RO5263397 attenuates the induction of cocaine behavioral sensitization in rats

Trace Amines and the Trace Amine-Associated Receptor 1: Pharmacology, Neurochemistry, and Clinical Implications

Trace Amines and the Trace Amine-Associated Receptor 1: Pharmacology, Neurochemistry, and Clinical Implications

Augmentation of methamphetamine-induced behaviors in transgenic mice lacking the trace amine-associated receptor 1

Trace Amine Associated Receptor 1 Signaling in Activated Lymphocytes

Effects of the Trace Amine Associated Receptor 1 Agonist RO5263397 on Abuse-Related Behavioral Indices of Methamphetamine in Rats

The trace amine-associated receptor 1 modulates methamphetamine's neurochemical and behavioral effects