NDLI: An updated view on horseradish peroxidases: recombinant production and biotechnological applications

Content Provider	PubMed Central
Author	Krainer, Florian W. Glieder, Anton
Abstract	Horseradish peroxidase has been the subject of scientific research for centuries. It has been used exhaustively as reporter enzyme in diagnostics and histochemistry and still plays a major role in these applications. Numerous studies have been conducted on the role of horseradish peroxidase in the plant and its catalytic mechanism. However, little progress has been made in its recombinant production. Until now, commercial preparations of horseradish peroxidase are still isolated from plant roots. These preparations are commonly mixtures of various isoenzymes of which only a small fraction has been described so far. The composition of isoenzymes in these mixed isolates is subjected to uncontrollable environmental conditions. Nowadays, horseradish peroxidase regains interest due to its broad applicability in the fields of medicine, life sciences, and biotechnology in cancer therapy, biosensor systems, bioremediation, and biocatalysis. These medically and commercially relevant applications, the recent discovery of new natural isoenzymes with different biochemical properties, as well as the challenges in recombinant production render this enzyme particularly interesting for future biotechnological solutions. Therefore, we reviewed previous studies as well as current developments with biotechnological emphasis on new applications and the major remaining biotechnological challenge—the efficient recombinant production of horseradish peroxidase enzymes.
Related Links	http://dx.doi.org/10.1007/s00253-014-6346-7
Ending Page	1625
Page Count	15
Starting Page	1611
File Format	PDF
ISSN	01757598
e-ISSN	14320614
Journal	Applied Microbiology and Biotechnology
Volume Number	99
Language	English
Publisher	Springer Berlin Heidelberg
Publisher Date	2015-02-01
Access Restriction	Open
Rights Holder	Springer Berlin Heidelberg
Subject Keyword	Biotechnology Applied Microbiology and Biotechnology Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Medicine Applied Microbiology and Biotechnology Biotechnology

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