NDLI: Short-term efficacy of recombinant human GH therapy in cured acromegaly patients with GH deficiency: a single-center experience

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Short-term efficacy of recombinant human GH therapy in cured acromegaly patients with GH deficiency: a single-center experience

Content Provider	PubMed Central
Author	Dutta, Pinaki Mahendran, Bhuvanesh Reddy, K. S. Ahluwalia, Jasmina Kim, Vaiphei Kochhar, R. K. Gupta, Prakamya Srinivasan, Anand Prakash, Mahesh Mukherjee, Kanchan Kumar Parthan, Girish Bhansali, Anil Shah, V. N.
Copyright Year	2015
Abstract	The effectiveness and short-term safety of recombinant human GH (r-hGH) in acromegaly patients with GH deficiency (GHD) after treatment are not well established. The study includes ten subjects with acromegaly who had GHD treated with r-hGH for 6 months. Control groups consisted of ten age-, gender-, and BMI-matched healthy subjects and ten active acromegaly patients who were treatment naïve. Body composition, quality of life (QoL), muscle strength, lipid profile, and cardiovascular risk factors were assessed in all subjects at baseline, and the same parameters were reassessed after 6 months of therapy with r-hGH in acromegaly with GHD. Repeat magnetic resonance imaging of the sella was performed in treated subjects. Optical colonoscopy was done and biopsies were taken from multiple sites for proliferation indices (Ki67). The median duration of GHD was 17.8 months and dose of r-hGH administered was 5.7±1.5 μg/kg per day. There was improvement in bone mineral content (P=0.01), bone mineral density (P=0.04), muscle strength (P<0.001), total cholesterol (P=0.003), high-density cholesterol (P<0.001), and QoL – score (P=0.005), and reduction in low-density cholesterol (P=0.003) and triglyceride (P=0.004) after treatment. There was no change in lean body mass, total body fat, hsCRP, lipoprotein (a), and fibrinogen levels. There was a modest increase in plasminogen activator inhibitor 1 (P=0.002), but it was lower compared with healthy controls and treatment naïve acromegalics (P=0.007). Six month-r-hGH therapy improves body composition, atherogenic lipid profile, QoL, and muscle strength in GHD patients who had acromegaly. Long-term prospective studies are needed to evaluate the effect of r-hGH therapy in these patients.
Related Links	http://dx.doi.org/10.1530/ec-14-0132
Ending Page	75
Page Count	11
Starting Page	65
File Format	PDF
ISSN	20493614
e-ISSN	20493614
Journal	Endocrine Connections
Issue Number	1
Volume Number	4
Language	English
Publisher	Bioscientifica Ltd
Publisher Date	2015-02-09
Access Restriction	Open
Rights Holder	Bioscientifica Ltd
Subject Keyword	Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Endocrinology, Diabetes and Metabolism Internal Medicine Endocrinology

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