NDLI: 5HTTLPR genotype moderates the longitudinal impact of early caregiving on externalizing behavior

Content Provider	PubMed Central
Author	Brett, Zoë H. Humphreys, Kathryn L. Smyke, Anna T. Gleason, Mary Margaret Nelson, Charles A. Zeanah, Charles H. Fox, Nathan A. Drury, Stacy S.
Abstract	We examined caregiver report of externalizing behavior from 12 to 54 months of age in 102 children randomized to care as usual in institutions or to newly-created high quality foster care. At baseline no differences by group or genotype in externalizing were found. However, changes in externalizing from baseline to 42 months of age were moderated by 5HTTLPR genotype and intervention group, where the slope for s/s individuals differed as a function of intervention group. The slope for individuals carrying the l allele did not significantly differ between groups. At 54 months of age, s/s children in the foster care group had the lowest levels of externalizing behavior, while children with the s/s genotype in the care as usual group demonstrated the highest rates of externalizing behavior. No intervention group differences were found in externalizing behavior among children who carried the l allele. These findings, within a randomized control trial of foster care compared to continued care as usual, indicate that 5HTTLPR genotype moderates the relation between early caregiving environments to predict externalizing behavior in children exposed to early institutional care in a manner most consistent with differential susceptibility.
Related Links	http://dx.doi.org/10.1017/s0954579414001266
Ending Page	18
Page Count	12
Starting Page	7
File Format	PDF
ISSN	09545794
e-ISSN	14692198
Journal	Development and psychopathology
Issue Number	1
Volume Number	27
Language	English
Publisher Date	2015-02-01
Access Restriction	Open
Subject Keyword	Developmental and Educational Psychology Psychiatry and Mental health Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Developmental and Educational Psychology Psychiatry and Mental Health

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