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| Content Provider | PubMed Central |
|---|---|
| Author | Taher, Chato Frisk, Gabriella Fuentes, Stina Religa, Piotr Costa, Helena Assinger, Alice Kannisto, Vetvik Katja Bukholm, Ida R. K. Yaiw, Koon-chu Ekström, Smedby Karin Bäcklund, Magnus Cecilia, Söderberg-naucler Rahbar, Afsar |
| Copyright Year | 2014 |
| Abstract | BACKGROUND: Brain metastases (BMs) develop by largely unknown mechanisms and cause major morbidity and mortality in patients with solid tumors. Human cytomegalovirus (HCMV) is frequently detected in tumor tissue from patients with different cancers. Here, we aimed to determine the prevalence and potential prognostic role of HCMV in BMs. METHODS: We obtained archived samples of BMs from 41 patients with breast cancer and 37 with colorectal cancer and paired primary tumor tissues from 13 and 12 patients in each respective group. In addition, primary breast cancer tissues from 15 patients were included. HCMV proteins were detected with an immunohistochemical technique and Western blot. HCMV nucleic acids were detected with TaqMan polymerase chain reaction (PCR) assay. RESULTS: HCMV proteins were abundantly expressed in 99% of BM specimens, and in 12 of 13 (92%) paired primary breast cancer specimens. All 12 paired colon cancer samples were positive for HCMV proteins. Protein staining was mainly confined to neoplastic cells. Western blot analysis detected an HCMV-IE reactive protein in 53% of breast cancer specimens, and PCR detected the presence of HCMV DNA and transcripts in 92% and 80% of samples, respectively. Patients with high-level expression of HCMV-IE proteins in their tumors had a shorter time to tumor progression and shorter overall survival. CONCLUSIONS: The prevalence of HCMV proteins and nucleic acids is very high in primary and metastatic tumors and may drive the development of metastatic brain tumors; therefore, this virus may represent a potential therapeutic target in metastatic cancer. |
| Related Links | http://dx.doi.org/10.1016/j.tranon.2014.09.008 |
| Ending Page | 740 |
| Page Count | 9 |
| Starting Page | 732 |
| File Format | |
| ISSN | 19365233 |
| e-ISSN | 19365233 |
| Journal | Translational Oncology |
| Issue Number | 6 |
| Volume Number | 7 |
| Language | English |
| Publisher | Neoplasia Press |
| Publisher Date | 2014-12-01 |
| Access Restriction | Open |
| Rights Holder | Neoplasia Press |
| Subject Keyword | Cancer Research Oncology Research in Higher Education |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cancer Research Oncology |
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