NDLI: BMP signaling is required for cell cleavage in preimplantation-mouse embryos

Content Provider	PubMed Central
Author	Mochel, Nabora Soledad Reyes De Luong, Mui Chiang, Michael Javier, Anna L. Luu, Elizabeth Fujimori, Toshihiko Macgregor, Grant R. Olivier, Cinquin Cho, Ken W. Y.
Copyright Year	2014
Abstract	The mechanisms regulating cell division during development of the mouse pre-implantation embryo are poorly understood. We have investigated whether bone morphogenetic protein (BMP) signaling is involved in controlling cell cycle during mouse pre-implantation development. We mapped and quantitated the dynamic activities of BMP signaling through high-resolution immunofluorescence imaging combined with a 3D segmentation method. Immunostaining for phosphorylated Smad1/5/8 shows that BMP signaling is activated in mouse embryos as early as the 4-cell stage, and becomes spatially restricted by late blastocyst stage. Perturbation of BMP signaling in preimplantation mouse embryos, whether by treatment with a small molecule inhibitor, with Noggin protein, or by over-expression of a dominant-negative BMP receptor, indicates that BMPs regulate cell cleavage up to the morula stage. These results indicate that BMP signaling is active during mouse pre-implantation development and is required for cell cleavage in preimplantation mouse embryos.
Related Links	http://dx.doi.org/10.1016/j.ydbio.2014.10.001
Ending Page	55
Page Count	11
Starting Page	45
File Format	PDF
ISSN	00121606
e-ISSN	1095564X
Journal	Developmental biology
Issue Number	1
Volume Number	397
Language	English
Publisher Date	2015-01-01
Access Restriction	Open
Subject Keyword	Developmental Biology Cell Biology Molecular Biology Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Cell Biology Developmental Biology Molecular Biology

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Gtpbp2 is required for BMP signaling and mesoderm patterning in Xenopus embryos

BMP signaling is required for cell cleavage in preimplantation-mouse embryos.

BMP-Smad4 signaling is required for precartilaginous mesenchymal condensation independent of Sox9 in the mouse

Bmp signaling is required for development of primary lens fiber cells

Ecsit is required for Bmp signaling and mesoderm formation during mouse embryogenesis

magu is required for germline stem cell self-renewal through BMP signaling in the Drosophila testis

Interplay between Notch signaling and the homeoprotein Xiro1 is required for neural crest induction in Xenopus embryos

Gbb/BMP signaling is required to maintain energy homeostasis in Drosophila

The Ras/Raf signaling pathway is required for progression of mouse embryos through the two-cell stage.

BMP signaling is required for cell cleavage in preimplantation-mouse embryos

Similar Documents

Gtpbp2 is required for BMP signaling and mesoderm patterning in Xenopus embryos

BMP signaling is required for cell cleavage in preimplantation-mouse embryos.

BMP-Smad4 signaling is required for precartilaginous mesenchymal condensation independent of Sox9 in the mouse

Bmp signaling is required for development of primary lens fiber cells

Ecsit is required for Bmp signaling and mesoderm formation during mouse embryogenesis

magu is required for germline stem cell self-renewal through BMP signaling in the Drosophila testis

Interplay between Notch signaling and the homeoprotein Xiro1 is required for neural crest induction in Xenopus embryos

Gbb/BMP signaling is required to maintain energy homeostasis in Drosophila

The Ras/Raf signaling pathway is required for progression of mouse embryos through the two-cell stage.

BMP signaling is required for cell cleavage in preimplantation-mouse embryos