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Common features in patients with intracerebral hemorrhage following superficial temporal artery-middle cerebral artery bypass in steno-occlusive cerebrovascular disease☆

Detection of cognitive impairment in patients with obstructive sleep apnea hypopnea syndrome using mismatch negativity☆

Neurodegenerative disease imaging evaluation and neural regeneration

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Detection of cognitive impairment in patients with obstructive sleep apnea hypopnea syndrome using mismatch negativity☆

Content Provider	PubMed Central
Author	Wen, Xiaohui Wang, Ningyu Liu, Jinfeng Yan, Zhanfeng Xin, Zhonghai
Copyright Year	2012
Abstract	In this experiment, 97 patients with obstructive sleep apnea hypopnea syndrome were divided into three groups (mild, moderate, severe) according to minimum oxygen saturation, and 35 healthy subjects were examined as controls. Cognitive function was determined using the mismatch negativity paradigm and the Montreal Cognitive Assessment. The results revealed that as the disease worsened, the mismatch negativity latency was gradually extended, and the amplitude gradually declined in patients with obstructive sleep apnea hypopnea syndrome. Importantly, mismatch negativity latency in severe patients with a persistent time of minimum oxygen saturation < 60 seconds was significantly shorter than that with a persistent time of minimum oxygen saturation > 60 seconds. Correlation analysis revealed a negative correlation between minimum oxygen saturation latency and Montreal Cognitive Assessment scores. These findings indicate that intermittent night-time hypoxemia affects mismatch negativity waveforms and Montreal Cognitive Assessment scores. As indicators for detecting the cognitive functional status of obstructive sleep apnea hypopnea syndrome patients, the sensitivity of mismatch negativity is 82.93%, the specificity is 73.33%, the accuracy rate is 81.52%, the positive predictive value is 85.00%, the negative predictive value is 70.21%, the positive likelihood ratio is 3, and the negative likelihood ratio is 0.23. These results indicate that mismatch negativity can be used as an effective tool for diagnosis of cognitive dysfunction in obstructive sleep apnea hypopnea syndrome patients.
Related Links	http://dx.doi.org/10.3969/j.issn.1673-5374.2012.20.010
Ending Page	1598
Page Count	8
Starting Page	1591
File Format	PDF
ISSN	18767958
e-ISSN	18767958
Journal	Neural Regeneration Research
Issue Number	20
Volume Number	7
Language	English
Publisher	Medknow Publications & Media Pvt Ltd
Publisher Date	2012-07-15
Access Restriction	Open
Rights Holder	Medknow Publications & Media Pvt Ltd
Subject Keyword	Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Developmental Neuroscience

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