NDLI: Goyazensolide Induces Apoptosis in Cancer Cells in vitro and in vivo.

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Goyazensolide Induces Apoptosis in Cancer Cells in vitro and in vivo.

Content Provider	PubMed Central
Author	Acuña, Ulyana Muñoz Shen, Qi Ren, Yulin Lantvit, Daniel D. Wittwer, Jennifer A. Kinghorn, A. Douglas Swanson, Steven M. Blanco, Esperanza J. Carcache De
Abstract	As part of the screening program for anticancer agents from natural sources, the sesquiterpene lactone goyazensolide (GZL) was identified as a potent NF-κB inhibitor. The hollow-fiber assay was used to evaluate the anti-tumor efficacy of GZL in vivo. The mechanistic effects of GZL were evaluated in the HT-29 colonic cell line to reveal the pathway through which GZL exerts its effects. NF-κB subunits p65 and p50 were inhibited, and the upstream mediator IκB kinase (IKKβ) was downregulated in a dose-dependent manner. Apoptosis was mediated by caspase-3, and cell cycle arrest was detected in G1-phase. Consequently, 96% of the cell population was in sub G1-phase after treatment with GZL (10 μM).The antitumor effect of GZL was observed at a dose of 12.5 mg/kg. Cell adhesion was affected as a result of NF-κB inhibition. GZL appears to selectively target the transcription factor NF-κB. In summary, GZL sensitizes HT-29 colon cancer cells to apoptosis and cell death in a dose-dependent manner both in vivo and in vitro, through NF-κB inhibition (IC50 = 3.8 μM). Thus, it is a new potent lead compound for further development into a new effective chemotherapeutic agent.
Related Links	http://dx.doi.org/10.3923/ijcr.2013.36.53
Ending Page	53
Page Count	18
Starting Page	36
File Format	PDF
ISSN	18119727
e-ISSN	18119735
Journal	International journal of cancer research
Issue Number	2
Volume Number	9
Language	English
Publisher Date	2013-02-01
Access Restriction	Open
Subject Keyword	Cancer Research Oncology Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Cancer Research Oncology

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