NDLI: The polarity of myxobacterial gliding is regulated by direct interactions between the gliding motors and the Ras homolog MglA

Content Provider	PubMed Central
Author	Nan, Beiyan Bandaria, Jigar N. Guo, Kathy Y. Fan, Xue Moghtaderi, Amirpasha Yildiz, Ahmet Zusman, David R.
Abstract	The bacterium Myxococcus xanthus moves on surfaces by directed gliding motility. MglA, a Ras family GTPase, regulates cell polarity in M. xanthus; However, little is known about how MglA establishes cell polarity during gliding, because gliding motors move simultaneously in opposite directions. We found that MglA interacts with the gliding motors directly and is localized in a decreasing intracellular gradient. Furthermore, the motors tend to reverse their moving direction at locations where the activity of MglA is high. Our data suggest that biased reversals along the MglA gradient make the motors moving toward the lagging cell poles less likely to reverse, generating stronger forward propulsion. Thus, bacterial cells, like eukaryotic cells, can use Ras homolog localization to establish cellular polarity.
Related Links	http://dx.doi.org/10.1073/pnas.1421073112
Starting Page	186
File Format	PDF
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	2
Volume Number	112
Language	English
Publisher	National Academy of Sciences
Publisher Date	2015-01-13
Access Restriction	Open
Rights Holder	National Academy of Sciences
Subject Keyword	General Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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The polarity of myxobacterial gliding is regulated by direct interactions between the gliding motors and the Ras homolog MglA