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| Content Provider | PubMed Central |
|---|---|
| Author | Mellor, Glen E. Fegan, Narelle Gobius, Kari S. Smith, Helen V. Jennison, Amy V. D'astek, Beatriz A. Rivas, Marta Shringi, Smriti Baker, Katherine N. K. Besser, Thomas E. |
| Editor | Diekema, D. J. |
| Copyright Year | 2015 |
| Abstract | While the differential association of Escherichia coli O157 genotypes with animal and human hosts has recently been well documented, little is known about their distribution between countries and how this might affect regional disease rates. Here, we used a 48-plex single nucleotide polymorphism (SNP) assay to segregate 148 E. coli O157 isolates from Australia, Argentina, and the United States into 11 SNP lineages. We also investigated the relationship between SNP lineages, Shiga toxin (Stx) gene profiles, and total Stx production. E. coli O157 isolates clearly segregated into SNP lineages that were differentially associated with each country. Of the 11 SNP lineages, seven were detected among isolates from a single country, two were detected among isolates from all three countries, and another two were detected only among U.S. and Argentinean isolates. A number of Australian (30%) and Argentinean (14%) isolates were associated with novel, previously undescribed SNP lineages that were unique to each country. Isolates within SNP lineages that were strongly associated with the carriage of stx 2a produced comparatively more Stx on average than did those lacking the stx 2a subtype. Furthermore, the proportion of isolates in stx 2a-associated SNP lineages was significantly higher in Argentina and the United States than Australia (P < 0.05). This study provides evidence for the geographic divergence of E. coli O157 and for a prominent role of stx 2a in total Stx production. These results also highlight the need for more comprehensive studies of the global distribution of E. coli O157 lineages and the impacts of regionally predominant E. coli O157 lineages on the prevalence and severity of disease. |
| Related Links | http://dx.doi.org/10.1128/jcm.01532-14 |
| Ending Page | 586 |
| Page Count | 8 |
| Starting Page | 579 |
| File Format | |
| ISSN | 00951137 |
| e-ISSN | 1098660X |
| Journal | Journal of Clinical Microbiology |
| Issue Number | 2 |
| Volume Number | 53 |
| Language | English |
| Publisher | American Society for Microbiology |
| Publisher Date | 2015-02-01 |
| Access Restriction | Open |
| Rights Holder | American Society for Microbiology |
| Subject Keyword | Microbiology (medical) Research in Higher Education |
| Content Type | Text |
| Resource Type | Article |
| Subject | Microbiology (medical) |
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