NDLI: Activation of Keap1/Nrf2 signaling pathway by nuclear epidermal growth factor receptor in cancer cells

Content Provider	PubMed Central
Author	Huo, Longfei Li, Chia-wei Huang, Tzu-hsuan Lam, Yung Carmen Xia, Weiya Tu, Chun Chang, Wei-chao Hsu, Jennifer L. Lee, Dung-fang Nie, Lei Yamaguchi, Hirohito Wang, Yan Lang, Jingyu Li, Long-yuan Chen, Chung-hsuan Mishra, Lopa Hung, Mien-chie
Copyright Year	2014
Abstract	Nuclear translocation of EGFR has been shown to be important for tumor cell growth, survival, and therapeutic resistance. Previously, we detected the association of EGFR with Keap1 in the nucleus. Keap1 is a Kelch-like ECH-associated protein, which plays an important role in cellular response to chemical and oxidative stress by regulating Nrf2 protein stability and nuclear translocation. In this study, we investigate the role of EGFR in regulating Keap1/Nrf2 cascade in the nucleus and provide evidence to show that nuclear EGFR interacts with and phosphorylates nuclear Keap1 to reduce its nuclear protein level. The reduction of nuclear Keap1 consequently stabilizes nuclear Nrf2 and increases its transcriptional activity in cancer cells, which contributes to tumor cell resistance to chemotherapy.
Ending Page	663
Starting Page	649
File Format	PDF
ISSN	19438141
e-ISSN	19438141
Journal	American Journal of Translational Research
Issue Number	6
Volume Number	6
Language	English
Publisher	e-Century Publishing Corporation
Publisher Date	2014-11-22
Access Restriction	Open
Rights Holder	e-Century Publishing Corporation
Subject Keyword	Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Clinical Biochemistry Cancer Research Molecular Medicine

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4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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