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| Content Provider | PubMed Central |
|---|---|
| Author | Hassan, Musa A. Saeij, Jeroen P. J. |
| Abstract | The nomination of candidate genes underlying complex traits is often focused on genetic variations that alter mRNA abundance or result in non-conservative changes in amino acids. Although inconspicuous in complex trait analysis, genetic variants that affect splicing or RNA editing can also generate proteomic diversity and impact genetic traits. Indeed it is known that splicing and RNA editing modulate several traits in humans and model organisms. Using high-throughput RNA sequencing (RNA-seq) analysis, it is now possible to integrate the genetics of transcript abundance, alternative splicing and editing with the analysis of complex traits. We recently demonstrated that both alternative splicing and mRNA editing are modulated by genetic and environmental factors, and potentially engender phenotypic diversity in a genetically segregating mouse population. Therefore, the analysis of splicing and RNA editing will expand not only the regulatory landscape of transcriptome and proteome complexity, but also the repertoire of candidate genes for complex traits. |
| Related Links | http://dx.doi.org/10.1002/bies.201400079 |
| Ending Page | 1040 |
| Page Count | 9 |
| Starting Page | 1032 |
| File Format | |
| ISSN | 02659247 |
| e-ISSN | 15211878 |
| Journal | BioEssays : news and reviews in molecular, cellular and developmental biology |
| Issue Number | 11 |
| Volume Number | 36 |
| Language | English |
| Publisher Date | 2014-11-01 |
| Access Restriction | Open |
| Subject Keyword | Biochemistry, Genetics and Molecular Biology(all) Research in Higher Education |
| Content Type | Text |
| Resource Type | Article |
| Subject | Biochemistry, Genetics and Molecular Biology |
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