NDLI: Synthesis of uniform cyclodextrin thioethers to transport hydrophobic drugs

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Synthesis of uniform cyclodextrin thioethers to transport hydrophobic drugs

Content Provider	PubMed Central
Author	Becker, Lisa F. Schwarz, Dennis H. Wenz, Gerhard
Editor	Zimmerman, Steven C.
Copyright Year	2014
Abstract	Methyl and ethyl thioether groups were introduced at all primary positions of α-, β-, and γ-cyclodextrin by nucleophilic displacement reactions starting from the corresponding per-(6-deoxy-6-bromo)cyclodextrins. Further modification of all 2-OH positions by etherification with iodo terminated triethylene glycol monomethyl ether (and tetraethylene glycol monomethyl ether, respectively) furnished water-soluble hosts. Especially the β-cyclodextrin derivatives exhibit very high binding potentials towards the anaesthetic drugs sevoflurane and halothane. Since the resulting inclusion compounds are highly soluble in water at temperatures ≤37 °C they are good candidates for new aqueous dosage forms which would avoid inhalation anaesthesia.
Related Links	http://dx.doi.org/10.3762/bjoc.10.310
Ending Page	2927
Page Count	8
Starting Page	2920
File Format	PDF
ISSN	18605397
e-ISSN	18605397
Journal	Beilstein Journal of Organic Chemistry
Volume Number	10
Language	English
Publisher	Beilstein-Institut
Access Restriction	Open
Rights Holder	Beilstein-Institut
Subject Keyword	Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Organic Chemistry

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