NDLI: CIRCULATING MICROPARTICLES IN PATIENTS WITH ANTIPHOSPHOLIPID ANTIBODIES: CHARACTERIZATION AND ASSOCIATIONS

Content Provider	PubMed Central
Author	Chaturvedi, Shruti Cockrell, Erin Espinola, Ricardo Hsi, Linda Fulton, Stacey Khan, Md Li, Liang Fonseca, Fabio Kundu, Suman Mccrae, Keith R.
Copyright Year	2014
Abstract	The antiphospholipid syndrome is characterized by venous or arterial thrombosis and/or recurrent fetal loss in the presence of circulating antiphospholipid antibodies. These antibodies cause activation of endothelial and other cell types leading to the release of microparticles with procoagulant and pro-inflammatory properties. The aims of this study were to characterize the levels of endothelial cell, monocyte, platelet derived, and tissue factor-bearing microparticles in patients with antiphospholipid antibodies, to determine the association of circulating microparticles with anticardiolipin and anti-β2-glycoprotein antibodies, and to define the cellular origin of microparticles that express tissue factor. Microparticle content within citrated blood from 47 patients with antiphospholipid antibodies and 144 healthy controls was analyzed within 2 hours of venipuncture. Levels of Annexin-V, CD105 and CD144 (endothelial derived), CD41 (platelet derived) and tissue factor positive microparticles were significantly higher in patients than controls. Though levels of CD14 (monocyte-derived) microparticles in patient plasma were not significantly increased, increased levels of CD14 and tissue factor positive microparticles were observed in patients. Levels of microparticles that stained for CD105 and CD144 showed a positive correlation with IgG (R = 0.60, p=0.006) and IgM anti-beta2-glycoprotein I antibodies (R=0.58, p=0.006). The elevation of endothelial and platelet derived microparticles in patients with APS and their correlation with anti-β 2 -glycoprotein I antibodies suggests a chronic state of vascular cell activation in these individuals and an important role for β2-glycoprotein I in development of the pro-thrombotic state associated with antiphospholipid antibodies.
Related Links	http://dx.doi.org/10.1016/j.thromres.2014.11.011
Ending Page	108
Page Count	7
Starting Page	102
File Format	PDF
ISSN	00493848
e-ISSN	18792472
Journal	Thrombosis research
Issue Number	1
Volume Number	135
Language	English
Publisher Date	2015-01-01
Access Restriction	Open
Subject Keyword	Hematology Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Hematology

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