NDLI: Tigecycline Therapy for Carbapenem-Resistant Klebsiella pneumoniae (CRKP) Bacteriuria Leads to Tigecycline Resistance

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Tigecycline Therapy for Carbapenem-Resistant Klebsiella pneumoniae (CRKP) Bacteriuria Leads to Tigecycline Resistance

Content Provider	PubMed Central
Author	Duin, David Van Cober, Eric Richter, Sandra S. Perez, Federico Cline, Marianne Kaye, Keith S. Kalayjian, Robert C. Salata, Robert A. Evans, Scott Fowler, Vance G. Bonomo, Robert A.
Abstract	Carbapenem-resistant Klebsiella pneumoniae (CRKP) is an increasing global threat. Here, we describe the prevalence and impact of tigecycline use in a cohort of patients with CRKP bacteriuria nested within a multicenter, prospective study. In the 21 month study period, 260 unique patients were included. Tigecycline was given to 80 (31%) patients. The use of tigecycline during the index hospitalization was significantly associated with the subsequent development of tigecycline resistance in the same patient (OR 6.13, 95%CI 1.15–48.65, p=0.03). In conclusion, the use of tigecycline with CRKP bacteriuria is common, and is associated with the subsequent development of tigecycline resistance.
Related Links	http://dx.doi.org/10.1111/1469-0691.12714
Starting Page	1117
File Format	PDF
ISSN	14690691
e-ISSN	14690691
Journal	Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases
Issue Number	12
Volume Number	20
Language	English
Publisher Date	2014-12-01
Access Restriction	Open
Subject Keyword	Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Infectious Diseases Microbiology (medical)

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