NDLI: Rituximab for Non-Hodgkin’s Lymphoma: A Story of Rapid Success in Translation

Content Provider	PubMed Central
Author	Harrison, Andrew M. Thalji, Nassir M. Greenberg, Alexandra J. Tapia, Carmen J. Windebank, Anthony J.
Abstract	Translational stories range from straightforward to complex. In this commentary, the story of the rapid and successful translation of rituximab therapy for the treatment of non-Hodgkin’s lymphoma (NHL) is examined. Development of this monoclonal antibody therapy began in the late 1980s. In 1994, rituximab received its first approval for the treatment of NHL by the United States Food and Drug Administration (FDA). Rituximab has since been approved for additional indications and has transformed medical practice. However, the social and political implications of these rapid successes are only beginning to become clear. In this commentary, key events in the rapid translation of rituximab from the bench to bedside are highlighted and placed into this historical framework. To accomplish this, the story of rituximab is divided into the following six topics, which we believe to be widely applicable to case studies of translation: (1) underlying disease, (2) key basic science, (3) key clinical studies in translation, (4) FDA approval process, (5) changes to medical practice, and (6) the social and political influences on translation.
Related Links	http://dx.doi.org/10.1111/cts.12111
Ending Page	86
Page Count	5
Starting Page	82
File Format	PDF
ISSN	17528054
e-ISSN	17528062
Journal	Clinical and translational science
Issue Number	1
Volume Number	7
Language	English
Publisher Date	2014-02-01
Access Restriction	Open
Subject Keyword	Pharmacology, Toxicology and Pharmaceutics(all) Biochemistry, Genetics and Molecular Biology(all) Neuroscience(all) Medicine(all) Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Neuroscience Medicine Biochemistry, Genetics and Molecular Biology Pharmacology, Toxicology and Pharmaceutics

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

LESSONS FROM THE SALK POLIO VACCINE: METHODS FOR AND RISKS OF RAPID TRANSLATION

Clinical and Translational Scientist Career Success: Metrics for Evaluation

Developing a Practice-Based Research Network by Integrating Quality Improvement: Challenges and Ingredients for Success

ClinicalTrials.gov Reporting: Strategies for Success at an Academic Health Center

THE CLINICAL TRANSLATION GAP IN CHILD HEALTH EXERCISE RESEARCH: A CALL FOR DISRUPTIVE INNOVATION

Pathways of Translation: Deep Brain Stimulation

The Sharing Partnership for Innovative Research in Translation (SPIRiT) Consortium: A Model for Collaboration across CTSA Sites

Using AI to Understand Key Success Features in Evolving CTSAs

TRANSLATION TO PRACTICE OF AN INTERVENTION TO PROMOTE COLORECTAL CANCER SCREENING AMONG AFRICAN AMERICANS

Rituximab for Non-Hodgkin’s Lymphoma: A Story of Rapid Success in Translation

Similar Documents

LESSONS FROM THE SALK POLIO VACCINE: METHODS FOR AND RISKS OF RAPID TRANSLATION

Clinical and Translational Scientist Career Success: Metrics for Evaluation

Developing a Practice-Based Research Network by Integrating Quality Improvement: Challenges and Ingredients for Success

ClinicalTrials.gov Reporting: Strategies for Success at an Academic Health Center

THE CLINICAL TRANSLATION GAP IN CHILD HEALTH EXERCISE RESEARCH: A CALL FOR DISRUPTIVE INNOVATION

Pathways of Translation: Deep Brain Stimulation

The Sharing Partnership for Innovative Research in Translation (SPIRiT) Consortium: A Model for Collaboration across CTSA Sites

Using AI to Understand Key Success Features in Evolving CTSAs

TRANSLATION TO PRACTICE OF AN INTERVENTION TO PROMOTE COLORECTAL CANCER SCREENING AMONG AFRICAN AMERICANS

Rituximab for Non-Hodgkin’s Lymphoma: A Story of Rapid Success in Translation