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| Content Provider | PubMed Central |
|---|---|
| Author | Qi, Shibo Bin, Li Yang, Tan Liu, Yong Cao, Shanshan He, Xingxing Zhang, Peng Lei, Li Xu, Chuanrui |
| Editor | Cho, William |
| Copyright Year | 2014 |
| Abstract | Bmi1 is a member of the polycomb group family of proteins, and it drives the carcinogenesis of various cancers and governs the self-renewal of multiple types of stem cells. Our previous studies have revealed that Bmi1 acts as an oncogene in hepatic carcinogenesis in an INK4a/ARF locus independent manner. However, whether Bmi1 can be used as a potential target for hepatocellular carcinoma treatment has not been fully confirmed yet. Here, we show that perturbation of Bmi1 expression by using short hairpin RNA can inhibit the tumorigenicity and tumor growth of hepatocellular carcinoma cells both in vitro and in vivo. Importantly, Bmi1 knockdown can block the tumor growth, both in the initiating stages and the fast growing stages. Cellular biology analysis revealed that Bmi1 knockdown induces cell cycle arrest and apoptosis. Our findings verify Bmi1 as a qualified treatment target for hepatocellular carcinoma (HCC) and support Bmi1 targeting treatment with chemotherapeutic agents. |
| Related Links | http://dx.doi.org/10.3390/ijms151120004 |
| Ending Page | 20021 |
| Page Count | 18 |
| Starting Page | 20004 |
| File Format | |
| ISSN | 14220067 |
| e-ISSN | 14220067 |
| Journal | International Journal of Molecular Sciences |
| Issue Number | 11 |
| Volume Number | 15 |
| Language | English |
| Publisher | MDPI |
| Publisher Date | 2014-11-01 |
| Access Restriction | Open |
| Rights Holder | MDPI |
| Subject Keyword | Research in Higher Education |
| Content Type | Text |
| Resource Type | Article |
| Subject | Spectroscopy Organic Chemistry Medicine Molecular Biology Physical and Theoretical Chemistry Catalysis Inorganic Chemistry Computer Science Applications |
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