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Next-generation sequencing of the mitochondrial genome and association with IgA nephropathy in a renal transplant population
| Content Provider | PubMed Central |
|---|---|
| Author | Douglas, Adam P. Vance, Dwaine R. Kenny, Elaine M. Morris, Derek W. Maxwell, Alexander P. Mcknight, Amy Jayne |
| Copyright Year | 2014 |
| Abstract | Kidneys are highly aerobic organs that are critically dependent on the normal functioning of mitochondria. Genetic variations disrupting mitochondrial function are associated with multifactorial disorders including kidney disease. This study sequenced the entire mitochondrial genome in a renal transplant cohort of 64 individuals, using next-generation sequencing, to evaluate the association of genetic variants with IgA nephropathy and end-stage renal disease (ESRD, n = 100). |
| Related Links | http://dx.doi.org/10.1038/srep07379 |
| Starting Page | 7379 |
| File Format | |
| ISSN | 20452322 |
| e-ISSN | 20452322 |
| Journal | Scientific Reports |
| Volume Number | 4 |
| Language | English |
| Publisher | Nature Publishing Group |
| Access Restriction | Open |
| Rights Holder | Nature Publishing Group |
| Subject Keyword | Science and technology Research in Higher Education |
| Content Type | Text |
| Resource Type | Article |
| Subject | Multidisciplinary |