Loading...
Please wait, while we are loading the content...
Similar Documents
Physiologically relevant, pH-responsive PEG-based block and statistical copolymers with N,N-diisopropylamine units†
| Content Provider | PubMed Central |
|---|---|
| Author | Lee, Annabelle Lundberg, Pontus Klinger, Daniel Lee, Bongjae F. Hawker, Craig J. Lynd, Nathaniel A. |
| Copyright Year | 2013 |
| Abstract | In order to impart pH-responsiveness within a physiologically-relevant context to PEG-based biomaterials, a new tertiary amine containing repeat unit, N,N-diisopropyl ethanolamine glycidyl ether (DEGE), was developed and incorporated into statistical and block copolymers with ethylene oxide (EO), and allyl glycidyl ether (AGE) via anionic ring-opening polymerization. The reactivity of this novel monomeric building block in copolymerizations with EO was investigated by spectroscopy with observed reactivity ratios of r DEGE = 1.28 ± 0.14 and r EO = 0.82 ± 0.10. It was further demonstrated that DEGE containing copolymers could serve as building blocks for the formation of new pH-responsive materials with a pK a of ca. 9, which allowed macroscopic hydrogels to be prepared from symmetric triblock copolymers PDEGE5.3k-b-PEO20k-b-PDEGE5.3k. The triblock copolymers exhibited clear sol-to-gel transitions in a physiologically-relevant critical gelation range of pH 5.8–6.6 and pH-dependent viscoelastic properties. On the nanometer scale, the preparation of pH-responsive micro- or nanogels was demonstrated by crosslinking P(DEGE-co-AGE) copolymers in miniemulsion droplets stabilized by PEO-b-P(DEGE-co-AGE) diblock terpolymers. These nanoparticles exhibited a reversible pH-dependent swelling profile with a volume phase transition at physiological pH 6.5–7.5. |
| Related Links | http://dx.doi.org/10.1039/c3py00747b |
| Starting Page | 5735 |
| File Format | |
| ISSN | 17599954 |
| e-ISSN | 17599962 |
| Journal | Polymer chemistry |
| Issue Number | 24 |
| Volume Number | 4 |
| Language | English |
| Publisher Date | 2013-01-01 |
| Access Restriction | Open |
| Subject Keyword | Organic Chemistry Biochemistry Bioengineering Polymers and Plastics Biomedical Engineering Research in Higher Education |
| Content Type | Text |
| Resource Type | Article |
| Subject | Organic Chemistry Biochemistry Bioengineering Biomedical Engineering Polymers and Plastics |
