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| Content Provider | PubMed Central |
|---|---|
| Author | Ma, Limin Liu, Hongchao Ruan, Linhai Yang, Xuewen Yang, Haiping Feng, Yanming |
| Copyright Year | 2015 |
| Abstract | Several studies have investigated the association between multidrug resistance gene (MDR1) C1236T polymorphism and leukemia risk, however, these published studies have yielded conflicting results. Thus, the present study carried out a meta-analysis to provide a more precise estimate of the effect of this polymorphism on the susceptibility to leukemia. The published case-control studies regarding the association between MDR1 C1236T polymorphism and leukemia risk were included following a computerized search of PubMed, Elsevier, The Cochrane Library, China National Knowledge Infrastructure and Wanfang Database. Either fixed- or random-effects models were applied to calculate the combined odds ratios (ORs) and 95% confidence intervals (CIs) by RevMan 5.2 software. Seven studies, including 846 cases and 1,523 controls, were included in the present meta-analysis. The results indicated that there was no significant association between the MDR1 C1236T polymorphism and leukemia risk in overall comparisons in all four genetic models (CT vs. CC: OR, 1.31, 95% CI, 0.89–1.91, P=0.17; TT vs. CC: OR, 2.16, 95% CI, 0.99–4.70, P=0.05; TT vs. CC+CT: OR, 1.72, 95% CI, 0.91–3.25, P=0.09; and CT+TT vs. CC: OR, 1.57, 95% CI, 0.96–2.56, P=0.07). In the subgroup analysis according to specific ethnicity, age and the type of leukemia, a significant association was found in adult leukemia (CT+TT vs. CC: OR, 2.77, 95% CI, 1.05–7.31, P=0.04) and chronic myeloid leukemia (CT vs. CC: OR, 1.71, 95% CI, 1.05–2.80, P=0.03). No significant publication bias was detected by funnel plot. Therefore, the meta-analysis indicated that the MDR1 C1236T polymorphism may contribute to the susceptibility to adult leukemia and chronic myeloid leukemia. Furthe well-designed studies based on larger sample sizes are required to validate these findings. |
| Related Links | http://dx.doi.org/10.3892/br.2014.387 |
| Starting Page | 83 |
| File Format | |
| ISSN | 20499434 |
| e-ISSN | 20499442 |
| Journal | Biomedical Reports |
| Issue Number | 1 |
| Volume Number | 3 |
| Language | English |
| Publisher | D.A. Spandidos |
| Publisher Date | 2014-11-01 |
| Access Restriction | Open |
| Rights Holder | D.A. Spandidos |
| Subject Keyword | Research in Higher Education |
| Content Type | Text |
| Resource Type | Article |
| Subject | Neuroscience Medicine Biochemistry, Genetics and Molecular Biology Pharmacology, Toxicology and Pharmaceutics |
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