NDLI: Severe Refractory Coeliac Disease with Response Only to Parenteral Nutrition

Content Provider	PubMed Central
Author	Ng, Ka Ying Bonnie Mehta, Ravi Mohamed, Salma Mohamed, Zameer Arnold, Jayantha
Copyright Year	2014
Abstract	Refractory coeliac disease (RCD) is characterised by recurrent or persistent malabsorptive symptoms and villous atrophy, despite strict adherence to a gluten-free diet for at least 6 months and where other causes of malabsorption including malignancy have been excluded. There is limited evidence and guidance on the effective management of these patients. We describe a case of severe RCD in our hospital, with symptoms controlled effectively only by total parenteral nutrition (TPN). This 68-year-old woman initially presented to the clinic with persistent non-bloody diarrhoea and vomiting. A diagnosis of coeliac disease was confirmed with a positive tissue transglutaminase assay and histology. A strict gluten-free diet was ineffective and she represented 6 months later with 13 kg weight loss (16.7%), ongoing abdominal pain and diarrhoea, with bowels opening 16 times a day. She was oedematous, had an albumin of 12 g/l and required hospital admission. She was treated for pancreatic insufficiency and presumptively for small bowel bacterial overgrowth with no resolution of symptoms. We ruled out infectious causes and investigated for small bowel malignancy; all results were negative. Small bowel enteroscopy showed ulcerative jejunitis. She was given 5 days of TPN, following which her symptoms improved and albumin normalised. This was sustained with symptom resolution and weight gain seen at follow-up. TPN successfully and rapidly induced remission in this case. Thus, a short period of TPN should be considered as a potential component of management in patients with severe RCD.
Related Links	http://dx.doi.org/10.1159/000368394
Ending Page	303
Page Count	7
Starting Page	297
File Format	PDF
ISSN	16620631
e-ISSN	16620631
Journal	Case Reports in Gastroenterology
Issue Number	2
Volume Number	8
Language	English
Publisher	S. Karger AG
Publisher Date	2014-10-01
Access Restriction	Open
Rights Holder	S. Karger AG
Subject Keyword	Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Gastroenterology

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