NDLI: Activation of Innate Immune-Response Genes in Little Brown Bats (Myotis lucifugus) Infected with the Fungus Pseudogymnoascus destructans

Content Provider	PubMed Central
Author	Rapin, Noreen Johns, Kirk Martin, Lauren Warnecke, Lisa Turner, James M. Bollinger, Trent K. Willis, Craig K. R. Voyles, Jamie Misra, Vikram
Editor	Sun, Jie
Copyright Year	2014
Abstract	Recently bats have been associated with the emergence of diseases, both as reservoirs for several new viral diseases in humans and other animals and, in the northern Americas, as hosts for a devastating fungal disease that threatens to drive several bat species to regional extinction. However, despite these catastrophic events little Information is available on bat defences or how they interact with their pathogens. Even less is known about the response of bats to infection during torpor or long-term hibernation. Using tissue samples collected at the termination of an experiment to explore the pathogenesis of White Nose Syndrome in Little Brown Bats, we determined if hibernating bats infected with the fungus Pseudogymnoascus destructans could respond to infection by activating genes responsible for innate immune and stress responses. Lesions due to fungal infection and, in some cases, secondary bacterial infections, were restricted to the skin. However, we were unable to obtain sufficient amounts of RNA from these sites. We therefore examined lungs for response at an epithelial surface not linked to the primary site of infection. We found that bats responded to infection with a significant increase in lungs of transcripts for Cathelicidin (an anti-microbial peptide) as well as the immune modulators tumor necrosis factor alpha and interleukins 10 and 23. In conclusion, hibernating bats can respond to experimental P. destructans infection by activating expression of innate immune response genes.
Related Links	http://dx.doi.org/10.1371/journal.pone.0112285
Starting Page	112285
File Format	PDF
ISSN	19326203
e-ISSN	19326203
Journal	PLoS ONE
Issue Number	11
Volume Number	9
Language	English
Publisher	Public Library of Science
Publisher Date	2014-11-01
Access Restriction	Open
Rights Holder	Public Library of Science
Subject Keyword	Biochemistry, Genetics and Molecular Biology(all) Agricultural and Biological Sciences(all) Medicine(all) Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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Influence of Urbanization on Demography of Little Brown Bats (Myotis lucifugus) in the Prairies of North America

Correction: Hibernating Little Brown Myotis (Myotis lucifugus) Show Variable Immunological Responses to White-Nose Syndrome

Host, Pathogen, and Environmental Characteristics Predict White-Nose Syndrome Mortality in Captive Little Brown Myotis (Myotis lucifugus)

Data from: Immune responses in hibernating little brown myotis (Myotis lucifugus) with white-nose syndrome (Dataset)

Specific Alterations in Complement Protein Activity of Little Brown Myotis (Myotis lucifugus) Hibernating in White-Nose Syndrome Affected Sites

Fungi on white-nose infected bats (Myotis spp.) in Eastern Canada show no decline in diversity associated with Pseudogymnoascus destructans (Ascomycota: Pseudeurotiaceae)

Data from: Conservation implications of ameliorating survival of little brown bats with White-Nose Syndrome (Dataset)

Resistance in persisting bat populations after white-nose syndrome invasion.

Environmental transmission of Pseudogymnoascus destructans to hibernating little brown bats

Activation of Innate Immune-Response Genes in Little Brown Bats (Myotis lucifugus) Infected with the Fungus Pseudogymnoascus destructans

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Influence of Urbanization on Demography of Little Brown Bats (Myotis lucifugus) in the Prairies of North America

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